Description:

Based on the seminal observations of Fletcher and Peto, modification of the accelerated decline in FEV1was considered the holy grail in initial clinical trials in COPD. Based on the concept of offering anti-inflammatory therapy, exacerbations and mortality were introduced as outcomes in large intervention studies. These studies have contributed to a tunnel perspective on COPD and a one size fits all approach to a complex heterogeneous syndrome.

Learning Objectives:

•A one size fits all approach is killing for profound understanding of underlying mechanisms of a disease condition.

•A personalized management strategy starts by understanding the heterogeneity of the COPD syndrome.