Chronic atrophied gastritis is the most important and independent risk factor for gastric adenocarcinoma, i.e., precancerous condition, especially in cases of intestinal metaplasia development.
Aiming the early detection of gastric cancer authors had conducted molecular-genetic researches in 60 patients with chronic atrophied gastritis. The objects of research were gastric mucosal layer taken from 3 points and blood samples. Polymerase chain reaction was used to determine the areas od DNA methylation in APC, E-cadherin, hMLHI and TINP3 genes.
Total hypomethylation was identified in 10 (16,6%) patients, in other 50 cases areas of DNA methylation were not found. Comparison of mucosal samples with blood samples revealed that the rate of concordance was in 7 cases (70%). In cases where we identified methylations in 3 and 4 genes in 2 patients was found stomach cancer.
In cases of identification of DNA areas methylation patients are recommended to undergo endoscopic monitoring every 6 months. In cases of absence of methylation endoscopy should be performed once a year.
National cancer Research Centre MoH Republic of Uzbekistan, Centre of High Technologies Academy of Sciences Republic of Uzbekistan
Has not received any funding
The author has declared no conflicts of interest.