Long noncoding RNAs (lncRNAs) are dysregulated in many cancer types and are believed to play crucial roles in regulating several hallmarks of cancer biology. However, the clinical significance of the lncRNA DANCR in rectal cancer is unclear. This study aims to investigate the prognostic value of lncRNA DANCR in upper rectal cancer patients.
In the present study, 50 patients with upper rectal carcinoma who did not receive neoadjuvant chemoradiation were included. qRT-PCR used to examine the relative level of lncRNA DANCR in tumor tissues and their adjacent non-tumor tissues. Patient demographics, tumor features and oncological outcomes were documented. Statistical analyses were performed with SPSS and web-based Sabiosciences PCR-Data Analysis programme.
The expression level of lncRNA DANCR was significantly higher in tumor tissues comparing to the matched non-tumor tissues (
In conclusion, over expression of lncRNA DANCR may be associated with poor outcomes in upper rectal cancer.
Berrin Tunca
Has not received any funding
All authors have declared no conflicts of interest.