Author Of 1 Presentation
LB1254 - A real-world data study of Coronavirus-2019 disease severity in patients with multiple sclerosis treated with ocrelizumab (ID 2150)
Abstract
Background
Ocrelizumab (OCR) is a B-cell depleting monoclonal antibody approved for the treatment of multiple sclerosis (MS), including relapsing and primary progressive forms of MS. The Coronavirus-2019 disease (COVID-19) pandemic raises concerns about clinical course and outcomes of COVID-19 in MS patients undergoing immunosuppressive treatment.
Objectives
To describe the clinical course and outcomes of COVID-19 in multiple sclerosis (MS) patients treated with ocrelizumab (OCR).
Methods
A retrospective cohort study of OCR treated MS patients with COVID-19 diagnosis who received treatment for COVID-19 in the Optum® de-identified COVID-19 Electronic Health Record (EHR) dataset. Inclusion criteria: confirmed COVID-19 diagnosis (ICD10 diagnosis, or positive diagnostic lab test since Feb 20th 2020), and OCR treatment ≤6 months prior to COVID-19 diagnosis. Patients with less than 28 days of follow-up were excluded. COVID-19 severity was categorized according to a 4 level ordinal scale based on worst status experienced during COVID-19 clinical course: 1) not hospitalized, 2) hospitalized, 3) hospitalized requiring invasive mechanical ventilation, 4) death. Secondary outcomes included the proportion of hospitalized patients diagnosed with respiratory failure, bacterial pneumonia, and sepsis on admission.
Results
As of 13 July 2020, there were EHRs for almost 128,000 patients with laboratory or clinically confirmed diagnosis of COVID-19. Forty-seven OCR treated patients were identified (32% male, median age 47 years, median Charlson comorbidity index 1.0, mean BMI 29.4 kg/m2, mean time since OCR initiation 1.3 years). Per COVID-19 severity scale, 75% (n=35) were not admitted to hospital, 21% (n=10) were hospitalized, 2% (n=1) required invasive ventilation and 2% (n=1) died. Compared to OCR cohort, Hospitalized patients (n=12) were older (median age 57.0 years) and consisted of proportionally more males (50%). On hospital admission, of patients not requiring ventilation, 40% (n=4) had respiratory failure, 10% (n=1) bacterial pneumonia and 0% sepsis, while both patients requiring ventilation, one of whom subsequently died, had respiratory failure and sepsis on admission.
Conclusions
In this large US cohort of confirmed/clinically COVID-19, a few treated with OCR were identified with majority experiencing mild disease not requiring hospitalization, and two patients suffering critical illness. This study provides initial real-world insights on the impact of COVID-19 in MS patients treated with OCR.
Presenter Of 1 Presentation
LB1254 - A real-world data study of Coronavirus-2019 disease severity in patients with multiple sclerosis treated with ocrelizumab (ID 2150)
Abstract
Background
Ocrelizumab (OCR) is a B-cell depleting monoclonal antibody approved for the treatment of multiple sclerosis (MS), including relapsing and primary progressive forms of MS. The Coronavirus-2019 disease (COVID-19) pandemic raises concerns about clinical course and outcomes of COVID-19 in MS patients undergoing immunosuppressive treatment.
Objectives
To describe the clinical course and outcomes of COVID-19 in multiple sclerosis (MS) patients treated with ocrelizumab (OCR).
Methods
A retrospective cohort study of OCR treated MS patients with COVID-19 diagnosis who received treatment for COVID-19 in the Optum® de-identified COVID-19 Electronic Health Record (EHR) dataset. Inclusion criteria: confirmed COVID-19 diagnosis (ICD10 diagnosis, or positive diagnostic lab test since Feb 20th 2020), and OCR treatment ≤6 months prior to COVID-19 diagnosis. Patients with less than 28 days of follow-up were excluded. COVID-19 severity was categorized according to a 4 level ordinal scale based on worst status experienced during COVID-19 clinical course: 1) not hospitalized, 2) hospitalized, 3) hospitalized requiring invasive mechanical ventilation, 4) death. Secondary outcomes included the proportion of hospitalized patients diagnosed with respiratory failure, bacterial pneumonia, and sepsis on admission.
Results
As of 13 July 2020, there were EHRs for almost 128,000 patients with laboratory or clinically confirmed diagnosis of COVID-19. Forty-seven OCR treated patients were identified (32% male, median age 47 years, median Charlson comorbidity index 1.0, mean BMI 29.4 kg/m2, mean time since OCR initiation 1.3 years). Per COVID-19 severity scale, 75% (n=35) were not admitted to hospital, 21% (n=10) were hospitalized, 2% (n=1) required invasive ventilation and 2% (n=1) died. Compared to OCR cohort, Hospitalized patients (n=12) were older (median age 57.0 years) and consisted of proportionally more males (50%). On hospital admission, of patients not requiring ventilation, 40% (n=4) had respiratory failure, 10% (n=1) bacterial pneumonia and 0% sepsis, while both patients requiring ventilation, one of whom subsequently died, had respiratory failure and sepsis on admission.
Conclusions
In this large US cohort of confirmed/clinically COVID-19, a few treated with OCR were identified with majority experiencing mild disease not requiring hospitalization, and two patients suffering critical illness. This study provides initial real-world insights on the impact of COVID-19 in MS patients treated with OCR.