Author Of 1 Presentation
LB1189 - Diagnostic Value of DWI-MRI for Detecting Acute Plaqes in Relapse Phase of Multiple Sclerosis (ID 1988)
Abstract
Background
The 2010 revision of McDonald Criteria for multiple sclerosis (MS) diagnosis have established that dissemination in time (DIT) can be demonstrated by simultaneous presence of asymptomatic gadolinium-enhancing and non-enhancing plaques on a single magnetic resonance imaging (MRI). Since gadolinium contrast agents have some contraindications, Diffusion-Weighted Imaging (DWI) can confirm diffusion alterations in active inflammatory plaques in these patients.
Objectives
The purpose of this study was to investigate whether DWI can be an alternative to the contrast-enhanced T1-weighted imaging for demonstrating DIT in MS.
Methods
We recruited 30 definite MS patients with acute relapse according to 2010 revision of the McDonald Criteria and evaluated their brain MRI via DWI‚ contrast-enhanced T1-weighted imaging and FLAIR sequences. Asymptomatic plaques were defined as either hyperintense or non-hyperintense on DWI and enhancing or non-enhancing on T1GAD-MRI. The statistical indices for prediction of plaque enhancement in T1 GAD-MRI via DWI-MRI were calculated.
Results
Thirty patients with 925 demyelinating plaque that were hyperintense in FLAIR-MRI and more than 3mm in size were enrolled. The diffusion hyperintensity and plaque enhancement were significantly correlated. The sensitivity‚ specificity ‚ positive predictive value‚ negative predictive value and accuracy were 69.66%‚99.76%‚96.88%‚96.86% and 96.86% respectively.
Conclusions
Hyperintense DWI findings do not necessarily overlap with contrast enhancements in T1 GAD-MRI, so cause many false positive results. Although T1 GAD-MRI may not be replaced by DWI to demonstrate DIT criteria due to low sensitivity, DWI may surrogate as a screening imaging sequence whenever the use of T1GAD-MRI be a concern.
Presenter Of 1 Presentation
LB1189 - Diagnostic Value of DWI-MRI for Detecting Acute Plaqes in Relapse Phase of Multiple Sclerosis (ID 1988)
Abstract
Background
The 2010 revision of McDonald Criteria for multiple sclerosis (MS) diagnosis have established that dissemination in time (DIT) can be demonstrated by simultaneous presence of asymptomatic gadolinium-enhancing and non-enhancing plaques on a single magnetic resonance imaging (MRI). Since gadolinium contrast agents have some contraindications, Diffusion-Weighted Imaging (DWI) can confirm diffusion alterations in active inflammatory plaques in these patients.
Objectives
The purpose of this study was to investigate whether DWI can be an alternative to the contrast-enhanced T1-weighted imaging for demonstrating DIT in MS.
Methods
We recruited 30 definite MS patients with acute relapse according to 2010 revision of the McDonald Criteria and evaluated their brain MRI via DWI‚ contrast-enhanced T1-weighted imaging and FLAIR sequences. Asymptomatic plaques were defined as either hyperintense or non-hyperintense on DWI and enhancing or non-enhancing on T1GAD-MRI. The statistical indices for prediction of plaque enhancement in T1 GAD-MRI via DWI-MRI were calculated.
Results
Thirty patients with 925 demyelinating plaque that were hyperintense in FLAIR-MRI and more than 3mm in size were enrolled. The diffusion hyperintensity and plaque enhancement were significantly correlated. The sensitivity‚ specificity ‚ positive predictive value‚ negative predictive value and accuracy were 69.66%‚99.76%‚96.88%‚96.86% and 96.86% respectively.
Conclusions
Hyperintense DWI findings do not necessarily overlap with contrast enhancements in T1 GAD-MRI, so cause many false positive results. Although T1 GAD-MRI may not be replaced by DWI to demonstrate DIT criteria due to low sensitivity, DWI may surrogate as a screening imaging sequence whenever the use of T1GAD-MRI be a concern.