Author Of 1 Presentation
P0797 - Cognitive Event-Related Potentials in Multiple Sclerosis. (ID 99)
Abstract
Background
Cognitive impairment (CI) affects 26-56% of multiple sclerosis (MS) patients. Previous studies have revealed that the cognitive P300 event-related potential (ERP) is substantially affected in cognitive impaired patients.
Objectives
To investigate the role of P300 ERP in MS. In specific we evaluated the diagnostic accuracy of the P300 ERP amplitude and latency in both the diagnosis of MS and the MS-related CI within patients.
Methods
Fifty-eight relapsing-remitting MS patients (41.9±10.3 years old, 41 women, disease duration 144.2±89.7 months, median EDSS 2.0) and 51 age- and gender-matched healthy controls participated in the study. Visual P300 ERP responses and Brief International Cognitive Assessment for MS (BICAMS) were evaluated. ROC curves were constructed to assess the diagnostic accuracy of P300 ERP.
Results
In total, 55.2% of the MS patients were identified with CI. P300 amplitude was significantly correlated with all cognitive functions (processing speed: rho=0.293, p=0.02, verbal memory: rho=0.505, p<0.001, visuospatial learning and memory: rho=0.494, p<0.001). P300 latency showed significant negative correlation with verbal memory (rho=-0.456, p<0.001) and visuospatial learning and memory (rho=-0.454, p<0.001) but not information processing speed (rho=-0.172, p=0.074). With regards to P300 amplitude, a cut-off lower than 7.7μV significantly distinguished MS patients from healthy controls (area under the curve or AUC=0.109±0.03, p<0.001, sensitivity=81%, specificity=92.2%). Among MS patients, a cut-off of 4.8μV distinguished CI from non-CI patients (AUC=0.311±0.07, p=0.014, sensitivity=56.3%, specificity=80.8%). A P300 latency cut-off higher than 305.5msecs significantly distinguished MS patients from healthy controls (AUC=0.931±0.02, p<0.001, sensitivity=79.3%, specificity=96.1%) but not CI status among MS patients (AUC=0.603±0.08, p=0.179).
Conclusions
P300 was ascertained as a potent diagnostic tool for MS diagnosis and even CI status. Based on these findings, we encourage the use of P300 ERP in the everyday clinical settings and the construction of normative values in the electrophysiological laboratories.