Author Of 1 Presentation
P1004 - A real-world study characterizing symptoms and impacts of fatigue in US adults with relapsing multiple sclerosis using a novel disease specific scale (ID 1135)
Abstract
Background
Fatigue is among the most frequent and disabling symptoms in relapsing multiple sclerosis (RMS) patients. A greater understanding of MS fatigue and associated, MS-specific patient reported outcomes tools to characterize fatigue and its impact would improve patient care.
Objectives
To measure MS fatigue and its impact on daily life in a real-world population using a survey including the RMS-specific Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple Sclerosis (FSIQ-RMS).
Methods
This is an ongoing noninterventional prospective study of ambulatory adult RMS patients recruited across the USA via an online survey. Participants completed demographic and clinical questionnaires including disease history and status, sleep, social and emotional functioning, along with the FSIQ-RMS, administered daily for 7 days. The FSIQ-RMS addresses the symptoms of fatigue, rated for severity based on the mean of the 7-day symptom assessment, and corresponding impacts of fatigue on 3 domains: physical, cognitive/emotional, and coping. The FSIQ-RMS scores range from 0-100 (higher score indicates greater severity). Data were collected via an online patient platform (Carenity).
Results
A total of 142 RMS patients completed the 7-day assessment: mean age: 43.5 yrs; 87% women; mean age at diagnosis: 33.2 yrs. Fatigue levels were severe and had high impact with a mean score during the 7-day period of 59.5 for the FSIQ-RMS symptom domain; 3 impact sub-domain scores were 45.1, 44.9 and 50.6 (physical, cognitive/emotional, and coping). The most impactful symptom on daily functioning was walking difficulties, followed by fatigue. A majority of patients (56%) experienced fatigue before MS diagnosis. Most patients (72%) were not currently relapsing and had a mean fatigue symptom domain score of 56.2 (vs 68 in relapsing patients). Those with lower disability tended to rate fatigue as the most impactful symptom on daily life. A majority of patients were not depressed (56%) nor reported a sleep disorder (72%), yet still reported mean fatigue symptom domain scores of 53.7, 58.1 respectively (vs 67, 63.3 in those with depression or sleep disorder). Heat exposure (82%) was the most common triggering factor for fatigue.
Conclusions
In this survey including the novel RMS specific FSIQ-RMS, fatigue occurred in most MS patients and had an influence on daily functioning. The FSIQ-RMS measures fatigue symptoms and impacts, which are relevant and meaningful to patients.
Presenter Of 1 Presentation
P1004 - A real-world study characterizing symptoms and impacts of fatigue in US adults with relapsing multiple sclerosis using a novel disease specific scale (ID 1135)
Abstract
Background
Fatigue is among the most frequent and disabling symptoms in relapsing multiple sclerosis (RMS) patients. A greater understanding of MS fatigue and associated, MS-specific patient reported outcomes tools to characterize fatigue and its impact would improve patient care.
Objectives
To measure MS fatigue and its impact on daily life in a real-world population using a survey including the RMS-specific Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple Sclerosis (FSIQ-RMS).
Methods
This is an ongoing noninterventional prospective study of ambulatory adult RMS patients recruited across the USA via an online survey. Participants completed demographic and clinical questionnaires including disease history and status, sleep, social and emotional functioning, along with the FSIQ-RMS, administered daily for 7 days. The FSIQ-RMS addresses the symptoms of fatigue, rated for severity based on the mean of the 7-day symptom assessment, and corresponding impacts of fatigue on 3 domains: physical, cognitive/emotional, and coping. The FSIQ-RMS scores range from 0-100 (higher score indicates greater severity). Data were collected via an online patient platform (Carenity).
Results
A total of 142 RMS patients completed the 7-day assessment: mean age: 43.5 yrs; 87% women; mean age at diagnosis: 33.2 yrs. Fatigue levels were severe and had high impact with a mean score during the 7-day period of 59.5 for the FSIQ-RMS symptom domain; 3 impact sub-domain scores were 45.1, 44.9 and 50.6 (physical, cognitive/emotional, and coping). The most impactful symptom on daily functioning was walking difficulties, followed by fatigue. A majority of patients (56%) experienced fatigue before MS diagnosis. Most patients (72%) were not currently relapsing and had a mean fatigue symptom domain score of 56.2 (vs 68 in relapsing patients). Those with lower disability tended to rate fatigue as the most impactful symptom on daily life. A majority of patients were not depressed (56%) nor reported a sleep disorder (72%), yet still reported mean fatigue symptom domain scores of 53.7, 58.1 respectively (vs 67, 63.3 in those with depression or sleep disorder). Heat exposure (82%) was the most common triggering factor for fatigue.
Conclusions
In this survey including the novel RMS specific FSIQ-RMS, fatigue occurred in most MS patients and had an influence on daily functioning. The FSIQ-RMS measures fatigue symptoms and impacts, which are relevant and meaningful to patients.