Johns Hopkins University School of Medicine
Neurology

Author Of 3 Presentations

Invited Presentations Invited Abstracts

PS15.01 - Disease Modifying Therapies and Retinal Atrophy

Speakers
Authors
Presentation Number
PS15.01
Presentation Topic
Invited Presentations
Lecture Time
12:45 - 13:00

Abstract

Abstract

Background: Although the retina represents an unmyelinated central nervous system structure, almost all aspects of multiple sclerosis (MS) related pathology (except demyelination) may be observed in the retina. Moreover, the retina represents an opportune site to study neurodegeneration, since optic nerve affliction is virtually ubiquitous in MS. Optical coherence tomography (OCT) derived measures of retinal neurodegeneration have been shown to strongly reflect the global MS disease process, and may be ideal outcomes for assessing neuroprotection, and/or neurorestoration. Accordingly, OCT outcomes are being increasingly incorporated as primary or secondary outcomes in MS clinical trials.

Goals: To describe the effects of MS disease modifying therapies (DMTs) on OCT derived assessment of retinal atophy.

Methods: Discussion of the emerging role of OCT for monitoring MS, as well as the effects of high-potency (including natalizumab and rituximab), and low-potency (including interferons and glatiramer acetate) MS DMTs on rates of OCT derived measures of composite ganglion cell+inner plexiform layer (GCIPL), inner nuclear layer (INL), and outer nuclear layer (ONL) atrophy. Differences in the effects of DMTs on retinal atrophy according to MS subtype will be reviewed. Finally, the role of the international MS visual system (IMSVISUAL) consortium in large scale MS studies will be discussed.

Results: Congruent with the effects of DMTs on rates of brain atrophy, high potency DMTs are associated with slower rates of retinal atophy in relapsing remitting MS (RRMS), as compared to low potency DMTs. Therepeutic optimization of the effect of rituximab on retinal atrophy in MS may take up to 6-12 months in RRMS. INL and ONL atrophy appear to be relatively speficic to progressive MS (PMS; both primary and secondary PMS), as compared to RRMS, and in PMS, INL and ONL atrophy are accelerated, independent of age. Rates of GCIPL, INL and ONL atrophy do not differ significantly between untreated PMS patients, and PMS patients treated with either low or high potency DMTs. Large scale MS studies utilizing visual system outcomes are facilitated by IMSVISUAL.

Conclusions: Rates of GCIPL atrophy are slower in RRMS patients treated with high potency, as compared to low potency DMTs. INL and ONL atrophy measures appear to be relatively specific to PMS, and may be novel outcomes for assessing neuroprotection and/or neurorestoration in PMS. Current, conventional, and primarily anti-inflammatory DMTs (whether high or low potency) have not been shown to significantly reduce retinal atophy in PMS, unlike RRMS.

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Neuro-Ophthalmology Oral Presentation

PS15.04 - The presence of epiretinal membranes in multiple sclerosis may be associated with increased disability

Speakers
Presentation Number
PS15.04
Presentation Topic
Neuro-Ophthalmology
Lecture Time
13:27 - 13:39

Abstract

Background

Neuroglial cells are implicated in the pathobiology of Multiple sclerosis (MS). Müller glia, specialized radial glial cells of the retina responsible for helping maintain retinal neuronal integrity, are postulated to be activated in MS. Müller glia activation is also implicated in epiretinal membrane (ERM) formation, an aberrant healing response to retinal damage.

Objectives

To examine ERM prevalence in MS, and differences in expanded disability status scale (EDSS) and optical coherence tomography (OCT) measured retinal layer thicknesses, between MS patients with (ERM-MS) and without ERMs (non-ERM-MS).

Methods

In this cross-sectional study, 1463 MS patients (2926 eyes) underwent Cirrus spectral-domain OCT (with automated macular layer segmentation). All scans underwent qualitative and quantitative quality control (QC), and ERM presence was recorded. Excluding patients with optic neuritis history, ERM-MS (n=48) were matched 1:1 to non-ERM-MS based on age, body mass index (BMI) and sex. Fellow eye layer thicknesses of ERM-MS were compared to the average binocular layer thicknesses of non-ERM-MS patients, to investigate the possibility of a phenotype effect. Mixed effects linear regression models were used in analyses.

Results

ERM prevalence in this MS cohort was 4.9%. Post-matching mean age and BMI were respectively 60.7 years (SD 6.3) and 28.2 kg/m2 (SD 9.6) in ERM-MS, and 60.4 years (SD 5.7) and 27.5 kg/m2 (SD 8.9) in non-ERM-MS (p=0.7 for both). Both groups had 77.1% females. Median EDSS was 4 (IQR 2.5-6.5) in ERM-MS and 3 (IQR 1.5-6) in non-ERM-MS (difference: 1.1, CI: 0.2 – 1.9, p=0.021). Mean ganglion cell-inner plexiform layer (GCIPL) thickness was 67.1 um (SD 6.5) in ERM-MS and 70.2 um (SD 6.2) in non-ERM-MS (difference: -3.1, CI: -6.3 – -0.1, p=0.049). Moreover, mean retinal pigment epithelium (RPE) thickness was 31.6 um (SD 1.3) in ERM-MS and 32.4 um (SD 0.9) in non-ERM-MS (difference: -0.7 um, CI: -1.3 - -0.1, p=0.017).

Conclusions

Our findings suggest ERM-MS patients phenotypically have higher EDSS scores, and lower GCIPL and RPE thicknesses, as compared to non-ERM-MS patients. Blood-retinal barrier disruption due to retinal inflammation, among other reasons, may activate Müller glia in MS. This may help explain our finding that ERM presence in MS may be associated with disability. Moreover, RPE cells may be recruited in the ERM formation process, similarly explaining our finding of reduced RPE thickness among ERM-MS patients.

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Neuromyelitis Optica and Anti-MOG Disease Oral Presentation

YI02.01 - Optic Neuritis-Independent Retinal Atrophy In Neuromyelitis Optica Spectrum Disorders

Speakers
Presentation Number
YI02.01
Presentation Topic
Neuromyelitis Optica and Anti-MOG Disease
Lecture Time
11:15 - 11:27

Abstract

Background

Prior studies have suggested that retinal neuro-axonal loss may occur in aquaporin-4 (AQP4)-IgG seropositive neuromyelitis optica spectrum disorder (NMOSD) in the absence of optic neuritis (ON), but data are conflicting.

Objectives

To examine whether patients with AQP4-IgG seropositive NMOSD exhibit progressive retinal neuro-axonal loss, independently of optic neuritis (ON) attacks.

Methods

In this single-center, longitudinal study, 32 AQP4-IgG+ NMOSD patients and 48 healthy controls (HC) were followed with serial spectral-domain optical coherence tomography (OCT). NMOSD patients with ON less than 6 months prior to baseline were excluded, while data from patients with ON during follow-up were censored at the last visit prior to ON. Rates of peri-papillary retinal nerve fiber layer (pRNFL) and macular ganglion cell+inner plexiform layer (GCIPL) thinning were compared between groups utilizing mixed-effects linear regression models adjusted for age, race and sex.

Results

Median follow-up duration was 4.3 years (IQR: 2.6 -7.5) for the NMOSD cohort and 4.0 years (IQR: 1.8 – 7.5) for the HC. We observed faster pRNFL (β=-0.25µm/year, 95%CI: -0.45 to -0.05, p=0.014) and GCIPL thinning (β=-0.09µm/year, 95%CI: -0.17 to 0, p=0.05) in NMOSD compared to HC eyes. This difference appeared to be driven by faster pRNFL and GCIPL thinning in NMOSD eyes without a history of ON compared to HC (GCIPL: β=-0.15µm/year, 95%CI: -0.25 to -0.05, p=0.005; pRNFL: β=-0.43µm/year, 95%CI: -0.67 to -0.19, p<0.001), while rates of pRNFL (β=-0.07µm/year , 95%CI: -0.31 to 0.16, p=0.53) and GCIPL (β=-0.01µm/year, 95%CI: -0.11 to 0.10, p=0.90) thinning did not differ between NMOSD-ON and HC eyes .

Furthermore, we explored the effects of non-ON relapses during follow-up on rates of pRNFL and GCIPL thinning. Ten patients had relapses during follow-up (9 transverse myelitis, 1 area postrema syndrome). Patients with relapses did not exhibit differences in rates of GCIPL (β=0.05µm/year, 95%CI:-0.10 to 0.20, p=0.51) or pRNFL thinning (pRNFL: β=0.08µm/year, 95%CI: -0.28 to 0.43, p=0.67), compared to those who were clinically stable.

Conclusions

In this longitudinal study, we observed progressive pRNFL and GCIPL atrophy in AQP4-IgG+ NMOSD eyes unaffected by ON. These results support that subclinical involvement of the anterior visual pathway may occur in AQP4-IgG+ NMOSD.

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Presenter Of 1 Presentation

Invited Presentations Invited Abstracts

PS15.01 - Disease Modifying Therapies and Retinal Atrophy

Speakers
Authors
Presentation Number
PS15.01
Presentation Topic
Invited Presentations
Lecture Time
12:45 - 13:00

Abstract

Abstract

Background: Although the retina represents an unmyelinated central nervous system structure, almost all aspects of multiple sclerosis (MS) related pathology (except demyelination) may be observed in the retina. Moreover, the retina represents an opportune site to study neurodegeneration, since optic nerve affliction is virtually ubiquitous in MS. Optical coherence tomography (OCT) derived measures of retinal neurodegeneration have been shown to strongly reflect the global MS disease process, and may be ideal outcomes for assessing neuroprotection, and/or neurorestoration. Accordingly, OCT outcomes are being increasingly incorporated as primary or secondary outcomes in MS clinical trials.

Goals: To describe the effects of MS disease modifying therapies (DMTs) on OCT derived assessment of retinal atophy.

Methods: Discussion of the emerging role of OCT for monitoring MS, as well as the effects of high-potency (including natalizumab and rituximab), and low-potency (including interferons and glatiramer acetate) MS DMTs on rates of OCT derived measures of composite ganglion cell+inner plexiform layer (GCIPL), inner nuclear layer (INL), and outer nuclear layer (ONL) atrophy. Differences in the effects of DMTs on retinal atrophy according to MS subtype will be reviewed. Finally, the role of the international MS visual system (IMSVISUAL) consortium in large scale MS studies will be discussed.

Results: Congruent with the effects of DMTs on rates of brain atrophy, high potency DMTs are associated with slower rates of retinal atophy in relapsing remitting MS (RRMS), as compared to low potency DMTs. Therepeutic optimization of the effect of rituximab on retinal atrophy in MS may take up to 6-12 months in RRMS. INL and ONL atrophy appear to be relatively speficic to progressive MS (PMS; both primary and secondary PMS), as compared to RRMS, and in PMS, INL and ONL atrophy are accelerated, independent of age. Rates of GCIPL, INL and ONL atrophy do not differ significantly between untreated PMS patients, and PMS patients treated with either low or high potency DMTs. Large scale MS studies utilizing visual system outcomes are facilitated by IMSVISUAL.

Conclusions: Rates of GCIPL atrophy are slower in RRMS patients treated with high potency, as compared to low potency DMTs. INL and ONL atrophy measures appear to be relatively specific to PMS, and may be novel outcomes for assessing neuroprotection and/or neurorestoration in PMS. Current, conventional, and primarily anti-inflammatory DMTs (whether high or low potency) have not been shown to significantly reduce retinal atophy in PMS, unlike RRMS.

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Invited Speaker Of 1 Presentation

Invited Presentations Invited Abstracts

PS15.01 - Disease Modifying Therapies and Retinal Atrophy

Speakers
Authors
Presentation Number
PS15.01
Presentation Topic
Invited Presentations
Lecture Time
12:45 - 13:00

Abstract

Abstract

Background: Although the retina represents an unmyelinated central nervous system structure, almost all aspects of multiple sclerosis (MS) related pathology (except demyelination) may be observed in the retina. Moreover, the retina represents an opportune site to study neurodegeneration, since optic nerve affliction is virtually ubiquitous in MS. Optical coherence tomography (OCT) derived measures of retinal neurodegeneration have been shown to strongly reflect the global MS disease process, and may be ideal outcomes for assessing neuroprotection, and/or neurorestoration. Accordingly, OCT outcomes are being increasingly incorporated as primary or secondary outcomes in MS clinical trials.

Goals: To describe the effects of MS disease modifying therapies (DMTs) on OCT derived assessment of retinal atophy.

Methods: Discussion of the emerging role of OCT for monitoring MS, as well as the effects of high-potency (including natalizumab and rituximab), and low-potency (including interferons and glatiramer acetate) MS DMTs on rates of OCT derived measures of composite ganglion cell+inner plexiform layer (GCIPL), inner nuclear layer (INL), and outer nuclear layer (ONL) atrophy. Differences in the effects of DMTs on retinal atrophy according to MS subtype will be reviewed. Finally, the role of the international MS visual system (IMSVISUAL) consortium in large scale MS studies will be discussed.

Results: Congruent with the effects of DMTs on rates of brain atrophy, high potency DMTs are associated with slower rates of retinal atophy in relapsing remitting MS (RRMS), as compared to low potency DMTs. Therepeutic optimization of the effect of rituximab on retinal atrophy in MS may take up to 6-12 months in RRMS. INL and ONL atrophy appear to be relatively speficic to progressive MS (PMS; both primary and secondary PMS), as compared to RRMS, and in PMS, INL and ONL atrophy are accelerated, independent of age. Rates of GCIPL, INL and ONL atrophy do not differ significantly between untreated PMS patients, and PMS patients treated with either low or high potency DMTs. Large scale MS studies utilizing visual system outcomes are facilitated by IMSVISUAL.

Conclusions: Rates of GCIPL atrophy are slower in RRMS patients treated with high potency, as compared to low potency DMTs. INL and ONL atrophy measures appear to be relatively specific to PMS, and may be novel outcomes for assessing neuroprotection and/or neurorestoration in PMS. Current, conventional, and primarily anti-inflammatory DMTs (whether high or low potency) have not been shown to significantly reduce retinal atophy in PMS, unlike RRMS.

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Author Of 5 Presentations

Neuro-Ophthalmology Late Breaking Abstracts

LB1217 - Macular pigment concentration and distribution in multiple sclerosis (ID 2084)

Speakers
Presentation Number
LB1217
Presentation Topic
Neuro-Ophthalmology

Abstract

Background

Oxidative stress is implicated in inflammation and neurodegeneration in multiple sclerosis (MS). Similar to the brain, the retina is susceptible to reactive oxygen species (ROS). Macular pigment (MP), consisting primarily of the carotenoids lutein (L) and zeaxanthin (Z) blocks deleterious blue light, and provides anti-oxidant protection. To date, there has been a paucity of study of MP in MS.

Objectives

To examine MP concentration and distribution in MS eyes relative to healthy control (HC) eyes using macular pigment optical density (MPOD) imaging.

Methods

In this cross-sectional study, 27 MS patients (47 eyes) and 19 HCs (37 eyes) underwent MPOD imaging on a Spectralis (Heidelberg) device. MP absorbs blue light, but allows the free passage of green light. MPOD imaging involves the subtraction of blue from green wavelength auto-fluorescence macular scans, providing the optical density (OD) of MP. Radii of interest for MPOD were 0°, 0.23°, 0.51°, 0.98° and 1.99° degrees of eccentricity from the fovea, as well as peak, and half-peak MPOD locations. Study participants completed dietary L & Z screening questionnaires. Mixed effects linear regression models were used in analyses.

Results

Mean MPOD at 0° was 0.52 density units (d.u.) (SD 0.14) in MS and 0.63 d.u. (SD 0.18) in HC eyes (difference: -0.10 d.u., CI: -0.18 - -0.01, p=0.027). The median MPOD peak location eccentricity was 0.08° (IQR: 0 - 0.12) in MS and 0.04° (IQR: 0 - 0.08) in HC eyes (difference: 0.10°, CI: 0.01 - 0.20, p=0.031). Mean MPOD at the peak location was -0.09 d.u. lower in MS eyes relative to HC eyes (CI: -0.18 - -0.01, p=0.04). In addition, the half-peak MPOD location, similar to the MPOD peak location, was situated further from the fovea in MS eyes relative to HC eyes (difference: 0.28°, CI: 0.10 - 0.47, p=0.002). Analyses adjusted for age, body mass index, sex, and L & Z dietary scores, showed similar differences for MPOD at 0° eccentricity, and at the peak MPOD location, between MS and HC eyes.

Conclusions

Our findings suggest MP concentrations are reduced in MS eyes, with peak and half-peak MPOD locations shifted further from the fovea than in HC eyes. Increases in ROS consuming antioxidant MPs, and/or dysfunction in proteins transferring carotenoids to the fovea, among other reasons, may help explain reductions in MPOD in MS eyes. Our preliminary finding warrant further study, in larger, prospective MS cohorts, including determination of their clinical relevance.

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Biomarkers and Bioinformatics Poster Presentation

P0036 - Cerebral hypometabolism is a marker of disease severity in multiple sclerosis: a non-invasive imaging study using T2-Relaxation-Under-Spin-Tagging MRI (ID 1856)

Speakers
Presentation Number
P0036
Presentation Topic
Biomarkers and Bioinformatics

Abstract

Background

Metabolic dysfunction at a cellular level is a crucial element of progressive neuronal dysfunction, and ultimately neurodegeneration in multiple sclerosis (MS). Changes in retinal superficial vascular plexus (SVP) density, which is known to be reduced in MS, may in part reflect metabolic demand in the neuronal layers of the retina, and could accordingly provide insight regarding concurrent metabolic alterations in the brain.

Objectives

To compare cerebral metabolism in people with MS (PwMS) to healthy controls (HCs) using T2-Relaxation-Under-Spin-Tagging (TRUST) and phase-contrast (PC) MRI, and assess whether cerebral hypometabolism is related to reduced SVP density measured using optical coherence tomography angiography (OCTA).

Methods

In this cross-sectional study, PwMS and HC underwent TRUST and PC MRI to derive the oxygen extraction fraction (OEF; a measure of the efficiency of cerebral tissue in extracting oxygen from circulating blood) and cerebral metabolic rate of oxygen consumption (CMRO2; a volume-adjusted measure of cerebral tissue metabolism). A subset of PwMS underwent OCTA, with quantification of retinal SVP density using a deep neural network based-algorithm. Statistical analyses were adjusted for age and intra-subject inter-eye correlations, where relevant.

Results

We included 49 PwMS and 80 HCs. Overall, OEF was lower, and CMRO2 trended towards being lower, in PwMS as compared to HCs (OEF: 35.9% [SD 5.1] vs. 40.9%, [SD 5.1], p=0.04; CMRO2: 156.3 umol/mL/min [SD 23.9] vs. 158.7 umol/mL/min [SD 19.9], p=0.08). Lower CMRO2 was associated with longer MS disease duration (p=0.02), higher expanded disability status scale score (p=0.01) and lower subcortical gray matter volume fraction (p=0.04). Additionally, lower CMRO2 was associated with higher age in PwMS (p=0.02), but not in HCs (p=0.19), in whom effective neurovascular coupling is expected to maintain a fairly constant rate with aging. Lower OEF correlated with lower retinal SVP density in PwMS (r=0.32, p=0.02).

Conclusions

Cerebral hypometabolism is evident in PwMS compared to HCs, and is associated with longer disease duration and greater disability. Furthermore, alterations in cerebral metabolism are mirrored by alterations in retinal SVP density, supporting the utility of these non-invasive imaging techniques to measure inter-linked pathobiological processes. The ability to detect metabolic dysfunction in-vivo in PwMS may help facilitate the identification of new therapeutic targets and outcome measures for clinical trials.

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Disease Modifying Therapies – Mechanism of Action Poster Presentation

P0397 - Switches to immune-reconstitution therapies in Europe and the United States: Analyses from annual retrospective patient chart audits (ID 980)

Speakers
Presentation Number
P0397
Presentation Topic
Disease Modifying Therapies – Mechanism of Action

Abstract

Background

There are currently two immune-reconstitution therapies (IRTs) licensed for relapsing multiple sclerosis (MS) - alemtuzumab (ALZ), an anti-CD52 monoclonal infusion, and cladribine (CdA), a short-course oral, T- and B-cell depletor.

Objectives

To review real world data of characteristics and disease-modifying treatment (DMT) history among EU and US patients switched to IRTs.

Methods

In 2019, 276 EU neurologists contributed online chart reviews for a retrospective audit of 1,266 MS patients who switched to a new DMT (ALZ: 77; CdA: 47) within the prior 3 months. In 2020, 204 US neurologists contributed 1,009 chart reviews (ALZ: 35; CdA: 21). Conducted at the .05 alpha level, independent samples t-test was used to test differences in means, and z-test (with Bonferroni correction) in proportions, between DMTs.

Results

Overall, IRT use was low, with slightly more patients switched to ALZ (EU: 6.1%; US: 3.5% of switch charts) than CdA (EU: 3.7%; US: 2.1%), except in Germany. While age, gender, recent relapse, and lesion counts did not differ by therapy or region, US patients treated with ALZ trended towards being diagnosed more recently compared to CdA-treated patients (mean: 30 vs. 68 months; p=0.058).

In the US, CdA was more likely than ALZ to be prescribed to patients with relapsing-remitting MS (RRMS) (86% vs. 60%; p=0.043) and trended towards being used less in RRMS patients with perceived risk for transition to secondary progressive MS transition (CdA: 17% vs. ALZ: 43%; p=0.077).

In both regions, most IRT switches were first DMT switches. In the EU, patients switched to CdA were more likely to have switched from an interferon (CdA: 28% vs. ALZ: 23%). In the US, glatiramer acetate more frequently preceded CdA (CdA: 38% vs. ALZ: 23%), while an anti-CD20 monoclonal antibody was more likely to have preceded ALZ (ALZ: 29% vs. CdA: 5%; p=0.030).

Conclusions

IRT treatment patterns in the EU and US are similar, with the exception of known differences in preceding injectable DMT use. In the US, patients are more likely to have been treated with anti-CD20 therapy before switching to ALZ than CdA, perhaps due to perceived differences in IRT efficacy profiles. ALZ is also more likely than CdA to be used among US patients diagnosed with, or at risk of transitioning to, progressive MS. Conversely, in the EU, the two IRTs are prescribed to very similar patient types.

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Neuromyelitis Optica and Anti-MOG Disease Poster Presentation

P0685 - AQP4-IgG and MOG-IgG related optic neuritis – prevalence, optical coherence tomography findings, visual outcomes: systematic review and meta-analysis (ID 860)

Speakers
Presentation Number
P0685
Presentation Topic
Neuromyelitis Optica and Anti-MOG Disease

Abstract

Background

Optic neuritis (ON) is a cardinal manifestation of multiple sclerosis (MS), aquaporin-4 (AQP4)-IgG, and myelin oligodendrocyte glycoprotein (MOG)-IgG associated disease. However, the prevalence of AQP4-IgG seropositivity and MOG-IgG seropositivity in isolated ON is unclear, and studies comparing visual outcomes and optical coherence tomography (OCT)-derived structural retinal measures between MS-ON, AQP4-ON, and MOG-ON eyes are limited by small sample sizes.

Objectives

1) To assess the prevalence of AQP4-IgG and MOG-IgG seropositivity among patients presenting with isolated ON; 2) To compare visual outcomes and OCT measures between AQP4-ON, MOG-ON, and MS-ON eyes.

Methods

In this systematic review and meta-analysis, a total of 65 eligible studies were identified by Pubmed search. Statistical analyses were performed with random-effects models.

Results

In adults with isolated ON, AQP4-IgG seroprevalence was 4% in non-Asian and 27% in Asian populations, whereas MOG-IgG seroprevalence was 8% and 20% respectively. In children, AQP4-IgG seroprevalence was 0.4% in non-Asian and 15% in Asian populations, whereas MOG-IgG seroprevalence was 47% and 31% respectively. AQP4-ON eyes had lower peri-papillary retinal nerve fiber layer (pRNFL; -11.7μm, 95% CI: -15.2 to -8.3μm) and macular ganglion cell + inner plexiform layer (GCIPL; -9.0μm, 95% CI -12.5 to -5.4μm) thicknesses compared with MS-ON eyes, but these measures did not differ between AQP4-ON and MOG-ON eyes (pRNFL: -1.9μm, 95% CI: -9.1 to 5.4μm; GCIPL: -2.6μm, 95% CI: -8.9 to 3.8μm). Similar to AQP4-ON, pRNFL (-11.2μm, 95% CI -21.5 to -0.9μm) and GCIPL (-6.1μm, 95% CI -10.8 to -1.3μm thicknesses were lower in MOG-ON compared to MS-ON eyes. Visual outcomes were worse in AQP4-ON compared to both MOG-ON (mean logMAR difference: 0.60, 95% CI 0.39 to 0.81) and MS-ON eyes (mean logMAR difference: 0.68, 95% CI 0.40 to 0.96), but were similar in MOG-ON and MS-ON eyes (mean logMAR difference: 0.04, 95% CI: -0.05 to 0.14).

Conclusions

AQP4-IgG and MOG-IgG associated disease are important diagnostic considerations in adults presenting with isolated ON, especially in Asian populations. Furthermore, MOG-IgG seroprevalence is especially high in pediatric isolated ON, in both non-Asian and Asian populations. Despite a similar severity of GCIPL and pRNFL thinning in AQP4-ON and MOG-ON, AQP4-ON is associated with markedly worse visual outcomes.

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Neuromyelitis Optica and Anti-MOG Disease Poster Presentation

P0713 - Evidence of subclinical quantitative retinal layer abnormalities in aquaporin-4-IgG seropositive NMOSD (ID 862)

Speakers
Presentation Number
P0713
Presentation Topic
Neuromyelitis Optica and Anti-MOG Disease

Abstract

Background

Aquaporin-4-IgG (AQP4-IgG) seropositive Neuromyelitis Optica Spectrum Disorder (NMOSD) typically presents with discrete attacks of optic neuritis (ON) and transverse myelitis, and insidious subclinical disease activity is considered a rare occurrence. Prior optical coherence tomography (OCT) studies have suggested that subclinical retinal abnormalities, including lower foveal thickness and altered foveal morphology, may be present in AQP4-IgG+ NMOSD in the absence of a clinical history of ON; however, existing studies were relatively small.

Objectives

To compare retinal layer thicknesses at the fovea and surrounding macula between AQP4-IgG+ NMOSD eyes without a history of ON (AQP4-nonON) and healthy controls (HC).

Methods

In this single-center cross-sectional study, 83 AQP4-nonON and 153 HC eyes were studied with spectral-domain OCT. Statistical analyses were performed with generalized estimating equations (GEE) and were adjusted for age, sex and race.

Results

Total foveal thickness did not differ between AQP4-nonON and HC eyes (-3.55±3.79μm, p=0.35). AQP4-nonON eyes exhibited lower outer nuclear layer (ONL) and inner photoreceptor segment (IS) thickness at the fovea (ONL: -4.01±2.03μm, p=0.049; IS: -0.32±0.14μm, p=0.029) and surrounding macula (ONL: -1.98±0.95μm, p=0.037; IS: -0.16±0.07μm, p=0.023), compared to HC. Macular retinal nerve fiber layer (mRNFL: -1.34±0.51μm, p=0.009) and ganglion cell + inner plexiform layer (GCIPL: -2.44±0.93μm, p=0.009) thicknesses were also lower in AQP4-nonON compared to HC eyes. The magnitude of the estimated differences was similar in sensitivity analyses restricted to AQP4-IgG+ patients who had never experienced ON in either eye (n=33 patients; mRNFL: -1.33±0.60μm, p=0.026; GCIPL: -2.59±1.12μm, p=0.021; macular ONL: -2.01±1.04μm, p=0.052; macular IS: -0.16±0.08μm, p=0.031; foveal ONL: -3.78±2.28μm, p=0.10; foveal IS: -0.28±0.19μm, p=0.14).

Conclusions

AQP4-nonON eyes exhibited evidence of subclinical retinal ganglion cell neuronal and axonal loss, as well as structural evidence of photoreceptor layer involvement. These results remained largely unaltered in analyses limited to patients who had never experienced ON, suggesting that they are likely related to processes that are independent of clinically overt ON attacks. These findings support that subclinical anterior visual pathway involvement may occur in AQP4-IgG+ NMOSD, and may relate to a primary retinal process or subclinical optic neuropathy.

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