Author Of 1 Presentation
P0899 - Prevalence of late-onset Multiple Sclerosis in Argentina: cross sectional study from RelevarEM (ID 1020)
Abstract
Background
Multiple Sclerosis (MS) tipically affects young adults; however, the first symptoms can occur after age 50 and is classified as late-onset MS (LOMS). Previous population-based studies described a frequency that ranged from 2 to 10% of LOMS, however scarce information exists in our region regarding this aspect.
Objectives
The objective of the present study was to describe the frecuency and clinical aspects of LOMS patients included in the Argentinean MS and NMOSD registry (Relevar EM, NCT 03375177).
Methods
Relevar EM is a longitudinal, strictly observational MS and NMOSD registry in Argentina. The eligible study population and cohort selection included all patients with definite MS included in the registry at 31 December 2019. LOMS was defined in MS patients in which the first symptom of disease was identified after the age of 50 years. Clinical and demographic aspects of the disease was described. Prevalence rate of LOMS and 95% CI was calculated.
Results
We included 2408 MS patients, mean age 42 (SD 8) years, 65.5% female. LOMS was identified 191 patients, prevalence rate 7.9%, 95% CI 6.85-9.01. In LOMS patients, 141 (68.5%) were female, mean age at disease onset 55 (SD 3.5) years. The mean EDSS was 3.5 (range 2-6). The most frequent first symptoms were motors deficits (33%) and multisystem deficits (33%). Most frequent clinical course (in all the cases with a minimal disease follow up of 3 years after the onset) was the relapsing remitting-MS (54.5%) fenotype. Primary progressive-MS in LOMS was observed in 20.9%. Oligoclonal IgG bands were positive in the 72 % of patients in the CSF study.
Conclusions
In our study we found a prevalence of LOMS of almost 8%. Most patients were RRMS. The frequency found in our cohort is like other population- based studies performed in Europe
Presenter Of 1 Presentation
P0899 - Prevalence of late-onset Multiple Sclerosis in Argentina: cross sectional study from RelevarEM (ID 1020)
Abstract
Background
Multiple Sclerosis (MS) tipically affects young adults; however, the first symptoms can occur after age 50 and is classified as late-onset MS (LOMS). Previous population-based studies described a frequency that ranged from 2 to 10% of LOMS, however scarce information exists in our region regarding this aspect.
Objectives
The objective of the present study was to describe the frecuency and clinical aspects of LOMS patients included in the Argentinean MS and NMOSD registry (Relevar EM, NCT 03375177).
Methods
Relevar EM is a longitudinal, strictly observational MS and NMOSD registry in Argentina. The eligible study population and cohort selection included all patients with definite MS included in the registry at 31 December 2019. LOMS was defined in MS patients in which the first symptom of disease was identified after the age of 50 years. Clinical and demographic aspects of the disease was described. Prevalence rate of LOMS and 95% CI was calculated.
Results
We included 2408 MS patients, mean age 42 (SD 8) years, 65.5% female. LOMS was identified 191 patients, prevalence rate 7.9%, 95% CI 6.85-9.01. In LOMS patients, 141 (68.5%) were female, mean age at disease onset 55 (SD 3.5) years. The mean EDSS was 3.5 (range 2-6). The most frequent first symptoms were motors deficits (33%) and multisystem deficits (33%). Most frequent clinical course (in all the cases with a minimal disease follow up of 3 years after the onset) was the relapsing remitting-MS (54.5%) fenotype. Primary progressive-MS in LOMS was observed in 20.9%. Oligoclonal IgG bands were positive in the 72 % of patients in the CSF study.
Conclusions
In our study we found a prevalence of LOMS of almost 8%. Most patients were RRMS. The frequency found in our cohort is like other population- based studies performed in Europe