Author Of 1 Presentation
P0489 - Relationship between comorbidities and health-related quality of life in patients with multiple sclerosis (ID 915)
Abstract
Background
Multiple sclerosis (MS) patients have reduced health-related quality of life (HRQoL) compared with those without MS in the same age group. The association between HRQoL and comorbidity has received considerable attention in the recent years, but limited studies have attempted to investigate the effect of comorbidities on HRQoL in MS patients.
Objectives
Our aim was to study the association between comorbidity and health-related quality of life in patients with multple sclerosis.
Methods
This cross-sectional study was conducted from July 10, 2018 to October 25, 2019. A total of 976 MS patients who visited MS clinic of Kashani Hospital were included in the study. Comorbidities were assessed through chart review. The 36-Item Short Form Survey (SF-36) was used to assess quality of life. The SF-36 results are presented in two categories of physical component summary (PCS) and mental component summary (MCS). We firstly evaluated the relation between any physical or mental comrbidity and HRQoL. Then, the association between all physical, psychiatric, or autoimmune comorbidities and HRQoL were investigated. Generalized linear model was applied to evaluate the relation between comorbidities and QOL (dependent variable), which were adjusted for sex, age, first and current EDSS and MS type.
Results
The mean PCS and MCS score were 44.81 (10.71) and 43.09 (11.13), respectively. Patients with epilepsy demonstrated less PCS score (B=-4.390; p=0.003) compared to those without epilepsy. Also, history of coronary heart disease and eye disorders have association with lower PCS, respectively with (B=-9.204; p=0.032) and (B=-11.43; p=0.008). The results showed that the women who were diagnosed with ovarian failure had lower level of MCS (B=-6.148; p=0.047). Furthermore, MCS (B=-7.862; p=0.015) was lower in women with polycystic ovary syndrome (PCO) compared to those without PCO. Regarding psychiatric comorbidities, we observed a significant association between OCD (B=-2.300; p=0.005), MDD (B=-2.373; p=0.013) and BPD (B=-5.398; p=0.001) with PCS, but not for GAD. Finally, OCD (B=-2.783; p=0.009) and MDD (B=-4.450; p<0.001) were associated with lower MCS in patients with MS. All physical comorbidities associated with less PCS (B=-1.592; p=0.005) and MCS (B=-1.943; p=0.009). Also, all psychological comorbidity have association with less PCS (B=-2.713; p<0.001) and MCS (B=-3.829; p<0.001). However, there was no association between the autoimmune comorbidities with PCS or MCS.
Conclusions
Our results show that both physical and psychiatric comorbidities associated with reduced quality of life in MS patients.