University of Padua
Department of Pediatrics

Author Of 1 Presentation

Pediatric MS Poster Presentation

P1072 - Cerebellar grey matter lesions are common in pediatric multiple sclerosis at clinical onset. (ID 126)

Speakers
Presentation Number
P1072
Presentation Topic
Pediatric MS

Abstract

Background

Background. No data are available on the occurrence of grey matter lesions (GML) in the cerebellum of pediatric multiple sclerosis (pedMS).

Objectives

Objectives. We analyzed frequency, number and topography of GML and their correlation with cerebellar-related disability in pedMS at clinical onset.

Methods

Methods. Fifteen adolescents with pedMS (12F/3M; mean age: 14.9±2.2, range 11–17) were studied. Neurological and cognitive evaluations were done by means of EDSS, Trail Making Test – Part B (TMT-B) and Symbol Digit Modalities Test – oral version (SDMT). Cerebellar GML were investigated with double inversion recovery (DIR) and phase sensitive inversion recovery (PSIR) sequences obtained with a 3T-MRI scan.

Results

Results. All patients had white matter lesions (WML) and/or GML in the cerebellum. A significantly higher GML number was observed on PSIR compared to DIR (mean: 2.3±2.3 vs 1.1±1.6; median: 2.0 (IQR, 1.0-2.0) vs 1.0 (IQR, 0.0-0.0.1); p=0.004). GML were observed in 14/15 (93.3%) patients and were more frequent in the posterior than in the anterior lobe (mean: 1.8±2.2 vs 0.47±0.74; median: 2.0 (IQR, 0.5-2.0) vs 0.0 (IQR, 0.0-1.0); p=0.044). No correlation was found between lesion number or topography and EDSS (r=0.12, p=0.69), TMT-B and SDMT.

Conclusions

Conclusions. At clinical onset, cerebellar GML are common in pedMS, are very often asymptomatic, do not correlate with physical and cognitive disability and more frequently affect the posterior lobe.

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