Author Of 1 Presentation
P0750 - Relation between helicobacter pylori infection and double seronegative neuromyelitis optica spectrum disorder (ID 551)
Abstract
Background
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinative disease in central nervous system. Different infectious agents’- bacteria, viruses and parasites, including the common flora- have a causal or protective role in NMOSD. Previous studies showed helicobacter pylori (H. pylori) was more common in optico-spinal multiple sclerosis and seropositive NMOSD patients compared to healthy individuals. However, their finding regarding difference between AQP4-IgG negative NMOSD and controls was different compared to seropositive patients. It has been hypothesized that H. pylori infection isn’t risk factor for developing of AQP4-Ab seronegative NMOSD.
Objectives
We conducted this study to survey association between Helicobacter pylori infection and double seronegative NMOSD patients.
Methods
We studied NMOSD patients were visited outpatient MS/NMOSD clinic of Kashani Hospital, affiliated to Isfahan University of Medical Sciences, Isfahan, Iran from October 2017 to May 2019. NMOSD patients with seronegative antibody against AQP4 and Myelin Oligodendrocyte Glycoprotein (MOG) in cell-based method were included in the study. Also, age and sex healthy control (HC) group comprised from the general population were enrolled. Demographic (age and sex) and clinical characteristics (EDSS score, disease duration, annualized relapse rate [ARR], and disease modifying therapies [DMTs] exposure) were recorded. We determined the seroprevalence of IgG and IgM antibodies against H. pylori. Association of seropositive IgG and IgM Ab against H. pylori with demographic and clinical features were assessed.
Results
A total of 35 NMOSD patients and 37 healthy controls were enrolled in the study. For NMOSD patients, mean age was 36.63±9.34; mean of disease duration was 6.33±3.10; mean of EDSS score was 1.54±1.19; and ARR was 0.54±0.29. The frequency of IgG and IgM Ab H. pylori seropositivity in NMOSD patients was 22.9% and 40.0%, respectively. Among HC, 11 (29.7%) and 20 (54.1%) were positive for IgG and IgM Ab H. pylori. Although the frequency of IgG and IgM Ab H. pylori seropositivity in HC were higher than NMOSD patients, these differences weren’t statistically significant. No clinical variables associated with H. pylori IgG and IgM seropositivity.
Conclusions
These finding show there is no possible relation between H. pylori infection and double seronegative NMOSD. Therefore it may be considered that non-specific inflammatory pathways alone cannot elucidate relation of double seronegative NMOSD with H. pylori infection.