Author Of 2 Presentations
P0029 - Assessment of Multiple Sclerosis Severity Score and Age-Related Multiple Sclerosis Severity Score as health indicators in a population-based cohort (ID 447)
Abstract
Background
Persons with multiple sclerosis (MS) present varying degrees of disability throughout the course of the disease. The Multiple Sclerosis Severity Score (MSSS) and the Age-Related Multiple Sclerosis Severity Score (ARMSSS) adjust the score obtained in the Expanded Disability Status Scale (EDSS) according to disease duration and age, respectively. These measures could be useful as health outcome indicators.
Objectives
The aim of this study was to describe the severity of MS in our health district and assess MSSS and ARMSSS consistency over time.
Methods
Patients diagnosed with MS according to 2010 McDonald criteria, with at least one year of disease duration and followed up in our MS unit within the previous 18 months were selected. Sex, age at onset, disease duration, clinical course, age and irreversible EDSS at last follow-up visit were collected. MSSS and ARMSSS were calculated. Our cohort was studied twice, in 2017 and 2020 to assess the consistency of both instruments.
Results
One hundred and seventy-seven patients were included in 2017, and 208 in 2020. Prevalence of MS in our health district was 90 and 105 per 100,000 inhabitants, respectively, in line with the expected prevalence. Median MSSS and ARMSSS were similar in both study years. In 2017, median MSSS was 1.77 (IQR 0.76-4.28) and ARMSSS was 2.9 (IQR 1.47-5.72). In 2020, median MSSS was 2.03 (IQR 0.82-4.36) and ARMSSS was 2.93 (IQR 1.51-5.56).
Conclusions
According to MSSS and ARMSSS, our cohort presented mild disease, and the results were consistent at both time points. MSSS and ARMSSS may be reliable health outcome measures.
P0840 - Benign Multiple Sclerosis: Is the EDSS scale enough to define it? (ID 436)
Abstract
Background
Benign multiple sclerosis (BMS) is a controversial concept. Most definitions only consider the Expanded Disability Status Scale (EDSS) and disease duration to define it, although other factors may influence patient’s disability.
Objectives
The aim of this study was to assess symptoms not evaluated or underestimated in the EDSS scale in patients with BMS defined as EDSS≤3 after 10 years of disease.
Methods
Patients were selected from a hospital-based series of 485 multiple sclerosis (MS) patients assessed in 1996. Those fulfilling the definition of BMS were selected. Patients were followed up in a prospective basis and EDSS were obtained after 20 and 30 years. At 30 years, the following test were completed: Patient Health Questionnaire (PHQ-9), Modified Fatigue Impact Scale (MFIS), Symbol Digit Modalities Test (SDMT) and Visual Analogue Scale (VAS) to evaluate severity of MS.
Results
82 from 485 patients evaluated in 1996 were selected. In 51 out of 68 (75%) patients evaluated in 2006 and in 35 out of 58 (60.3%) in 2016, the EDSS remained ≤3. Eighteen from the 35 BMS patients completed the questionnaire. 9/18 (50%) showed fatigue in the MFIS, 4/18 (22%) depression in the PHQ-9 and 15/18 (83%) cognitive impairment in the SDMT. 11/18 (61%) perceived their illness as more severe than estimated by the Multiple Sclerosis Severity Scale (MSSS). Fatigue and depression results were similar to those obtained in the rest of our MS patients (47.3% fatigue, 31% depression).
Conclusions
In patients with BMS, fatigue and depression frequency is similar to that of our MS cohort. A high percentage of patients present cognitive impairment, although it could be influenced by the older age of the patients.
Presenter Of 1 Presentation
P0840 - Benign Multiple Sclerosis: Is the EDSS scale enough to define it? (ID 436)
Abstract
Background
Benign multiple sclerosis (BMS) is a controversial concept. Most definitions only consider the Expanded Disability Status Scale (EDSS) and disease duration to define it, although other factors may influence patient’s disability.
Objectives
The aim of this study was to assess symptoms not evaluated or underestimated in the EDSS scale in patients with BMS defined as EDSS≤3 after 10 years of disease.
Methods
Patients were selected from a hospital-based series of 485 multiple sclerosis (MS) patients assessed in 1996. Those fulfilling the definition of BMS were selected. Patients were followed up in a prospective basis and EDSS were obtained after 20 and 30 years. At 30 years, the following test were completed: Patient Health Questionnaire (PHQ-9), Modified Fatigue Impact Scale (MFIS), Symbol Digit Modalities Test (SDMT) and Visual Analogue Scale (VAS) to evaluate severity of MS.
Results
82 from 485 patients evaluated in 1996 were selected. In 51 out of 68 (75%) patients evaluated in 2006 and in 35 out of 58 (60.3%) in 2016, the EDSS remained ≤3. Eighteen from the 35 BMS patients completed the questionnaire. 9/18 (50%) showed fatigue in the MFIS, 4/18 (22%) depression in the PHQ-9 and 15/18 (83%) cognitive impairment in the SDMT. 11/18 (61%) perceived their illness as more severe than estimated by the Multiple Sclerosis Severity Scale (MSSS). Fatigue and depression results were similar to those obtained in the rest of our MS patients (47.3% fatigue, 31% depression).
Conclusions
In patients with BMS, fatigue and depression frequency is similar to that of our MS cohort. A high percentage of patients present cognitive impairment, although it could be influenced by the older age of the patients.