Teaching Course Fri, Sep 11, 2020
Moderators
  • K. Fujihara
  • J. Palace
  • J. Bennett
Session Type
Teaching Course
Date
Fri, Sep 11, 2020
Invited Presentations Invited Abstracts

TC03.01 - Understanding the pathophysiology of AQP4 and MOG antibody diseases (ID 594)

Speakers
  • J. Bennett
Authors
  • J. Bennett
Presentation Number
TC03.01
Presentation Topic
Invited Presentations

Abstract

Abstract

Neuromyelitis optica (NMO) was historically defined by the concurrent or sequential presentation of optic neuritis and transverse myelitis. Serum autoantibodies against aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) have been identified in patients meeting clinical criteria for NMO and neuromyelitis optica spectrum disorders (NMOSD). Despite their clinical overlap, these two autoantibody-defined inflammatory disorders present with diverse neurologic findings across the pediatric and adult populations, distinct lesion histopathology, and disparate pathophysiology in experimental animal models. Therefore, it is important to be able to rapidly distinguish these conditions based on clinical, radiologic, and laboratory data due to differences in both their prognosis as well as their acute and chronic treatments. This lecture will focus on distinguishing these disorders based on their clinical phenotypes, MRI imaging, serologic assays, mechanisms of antibody-mediated pathogenesis, and histopathology.

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Invited Presentations Invited Abstracts

TC03.02 - 2 Antibody Neg Nmo like Syndromes: Unravelling the Diagnosis and How to Manage Them (ID 593)

Speakers
  • J. Palace
Authors
  • J. Palace
Presentation Number
TC03.02
Presentation Topic
Invited Presentations
Invited Presentations Invited Abstracts

TC03.03 - The Treatment of Nmosd: A New Era of Choice (ID 595)

Speakers
  • K. Fujihara
Authors
  • K. Fujihara
Presentation Number
TC03.03
Presentation Topic
Invited Presentations