Epidemiology Poster Presentation

P0427 - Absence of latitudinal gradient in oligoclonal bands prevalence in Argentina (ID 858)

Speakers
  • L. Negrotto
Authors
  • L. Negrotto
  • M. Marrodan
  • M. Fiol
  • M. Gaitán
  • M. Ysrraelit
  • C. Vrech
  • A. Pappolla
  • J. Miguez
  • L. Patrucco
  • E. Cristiano
  • J. Rojas
  • A. Carra
  • A. Chertcoff
  • J. Steinberg
  • A. Martinez
  • C. Curbelo
  • L. Cohen
  • R. Alonso
  • O. Garcea
  • C. Pita
  • B. Silva
  • G. Luetic
  • N. Deri
  • M. Balbuena
  • V. Tkachuk
  • E. Carnero Contentti
  • P. Lopez
  • J. Pettinicchi
  • A. Caride
  • M. Burgos
  • F. Leguizamon
  • E. Knorre
  • R. Piedrabuena
  • A. Barboza
  • S. Liwacki
  • P. Nofal
  • G. Volman
  • A. Alves Pinheiro
  • J. Hryb
  • D. Tavolini
  • P. Blaya
  • L. Recchia
  • C. Mainella
  • M. Kohler
  • E. Kohler
  • J. Blanche
  • S. Tizio
  • M. Saladino
  • F. Caceres
  • N. Fernandez Liguori
  • L. Lazaro
  • G. Zanga
  • M. Parada Marcilla
  • M. Fracaro
  • F. Pagani Cassará
  • G. Vazquez
  • V. Sinay
  • G. Sgrilli
  • P. Divi
  • M. Jacobo
  • E. Silva
  • E. Reich
  • L. Cabrera
  • M. Menichini
  • M. Coppola
  • I. Martos
  • J. Viglione
  • G. Jose
  • S. Bestoso
  • R. Manzi
  • D. Giunta
  • M. Doldan
  • M. Alonso Serena
  • J. Correale
Presentation Number
P0427
Presentation Topic
Epidemiology

Abstract

Background

Similarly, to what occurs with MS prevalence, it has been previously described that oligoclonal bands (OCB) prevalence follows a latitudinal gradient being more frequent farther away from the equator. Argentina has the particularity of being longitudinally extensive (21°46’S to 66°13’S). Previous epidemiological studies from Argentina have not found an MS prevalence latitudinal gradient.

Objectives

The aim of the present study is to describe the prevalence of OCB in CSF in patients with MS, CIS and RIS included in the Argentinean MS and NMOSD registry (RelevarEM, NCT 03375177) and to investigate if the prevalence follows a latitudinal gradient.

Methods

RelevarEM is a longitudinal, observational MS and NMOSD registry in Argentina. For each province, an average latitude was calculated using extreme N and S latitudes obtained from Google Maps. Regarding OCB, pattern II or III where considered as positive. The frequency of OCB was calculated for each diagnostic category (MS, CIS, RIS) and for each province. Statistical analysis was carried out using SPSS v22. Multivariate logistical regression analysis was performed considering OCB as a dichotomic dependent variable and latitude as an ordinal independent variable, adjusted by clinically relevant variables. Also, the percentage of patients OCB positive for each province was calculated and linear correlation was tested.

Results

We included 2866 patients from different locations in Argentina (92.4% MS, 5.8% CIS and 1.8% RIS). The mean age at diagnosis (SD) was 32.7 (11.2), 35.2 (10.7) and 40.7 (11.2) for MS, CIS and RIS patients, respectively. Lumbar puncture was performed in 54.6%, 63.9%, and 43.4% of MS, CIS and RIS patients, respectively. OCB where positive in 75.4%, 55.7% and 60.9% of MS, CIS and RIS patients, respectively. No association was found between OCB positivity and latitude, adjusted by gender, age at diagnosis and diagnostic category. No linear correlation was found between the percentage of OCB positive patients and latitude.

Conclusions

Similarly, to what has been described regarding MS prevalence, OCB positivity does not seem to follow a latitudinal gradient in Argentina. Also, OCB positivity in our study is lower that described in previous reports from other world regions.

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