Abstract

Multiple sclerosis immunotherapy can be generally classified into four categories:

General and selective immunesuppression,
Immuno modulation,
leucocyte sequestration,
Immune selective depletion

Furthermore one can distinguish ongoing therapies versus so called immune depletion and repopulations therapies (or alternatively called IRTs - immune reconstitution therapies). The talk will cover strategies and examples how especially the peripheral immune system can be manipulated to excerpt beneficial effects within in the central nervous system. Modern approaches to measure those effects are presented, especially in categories of immunomodulation, leucocyte sequestration and immune depletion and repopulation therapies.