Welcome to the 2021 LUPUS CORA Meeting Program Scheduling
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LUPUS Topics || ASC03 BIOMARKERS IN SLE, No Topic Needed
- Jill Buyon (United States of America)
- Dimitrios Bogdanos (Greece)
Clinical and Multiomics Studies of SLE.
- Sang-Cheol Bae (Korea, Republic of)
Live Q&A
Useful biomarkers for early diagnosis of SLE
- Chaim Putterman (United States of America)
Live Q&A
Biomarkers for lupus nephritis
- Ricard Cervera (Spain)
Live Q&A
DYSREGULATED ENDOTHELIAL MARKERS IN SYSTEMIC LUPUS ERYTHEMATOSUS: A SYSTEMATIC REVIEW AND META-ANALYSIS
- Sandy Bergkamp (Netherlands)
Abstract
Background and Aims
Background: Systemic Lupus Erythematosus (SLE) patients are at risk for premature atherosclerosis at relatively young age. Endothelial dysregulation is one of the pathophysiologic mechanisms that lead to higher risk for cardiovascular disease in SLE.
Objectives: To perform a systematic literature review on endothelial markers that are dysregulated in SLE and investigate potential associations with disease activity.
Methods
Methods: Search terms were entered into Embase, MEDLINE, Web of Science, Google Scholar and Cochrane. Inclusion criteria were 1) studies published after 2000 reporting measurements of endothelial cell (EC) markers in serum and/or plasma of SLE patients (diagnosed according to ACR/SLICC criteria), 2) English language peer reviewed articles, and 3) disease activity measurement.
Results
Results: From 1892 hits, 124 eligible articles were selected. The identified endothelial markers were involved in endothelial cell (EC) activation, EC apoptosis, disturbed angiogenesis, defective vascular tone control, immune dysregulation and coagulopathy. Meta-analyses of primarily cross-sectional studies showed significant associations between marker levels and disease activity for the following endothelial markers: Pentraxin-3, GAS6, Thrombomodulin, VEGF, ICAM-1, and MCP-1. Other dysregulated markers, without associations with disease activity, were: Angiopoeitin-2, Neopterin, vWF, P-Selectin, VCAM-1, TWEAK, IP-10 and E-Selectin
Conclusions
Conclusions: We provide a complete literature overview for dysregulated endothelial markers in SLE comprising a wide range of different endothelial functions. SLE-induced endothelial marker dysregulation was seen with and without association with disease activity.Longitudinal data on endothelial markers in SLE are now needed to guide us in unravelling the pathophysiology of premature atherosclerosis and cardiovascular events in SLE patients in young adulthood.
Live Q&A
RELATIONSHIP BETWEEN RETINAL MICROVASCULAR ALTERATIONS ASSESSED BY OCT-ANGIOGRAPHY AND KIDNEY INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS: A PILOT STUDY
- Sara Ferrigno (Italy)
Abstract
Background and Aims
Lupus Nephritis (LN) and retinopathy are SLE organ-threatening manifestations sharing common pathophysiology represented by immune-mediated microvascular damage. OCT-angiography (OCTA) is a non-invasive technique showing retinal microvascularity. Aim of this study is to investigate correlations between ocular and renal functional-histological involvement.
Methods
SLE-LN patients and healthy controls (HC), age and sex-matched, underwent a rheumatological, histological and ophthalmological evaluation (Figure1), including OCTA evaluation of superficial and deep retinal vessel density (VD), parafovea and fovea thickness, fovea avascular zone (FAZ) area and perimeter.
Statistical analysis was performed using: χ2, unpaired t-test, Mann Whitney U test, Pearson or Spearman rank correlation coefficient and ROC analysis.
Results
48 eyes of 24 SLE-LN patients and 42 eyes of 21 HC were evaluated. OCTA data analysis, displayed in Figure 2 with corresponding ROC, showed a reduction in superficial and deep retinal VD,parafovea and fovea thickness, an increase in FAZ area and perimeter in SLE-LN compared to HC (Figure 2).
OCTA data were correlated with SLE clinical features, showing negative correlation between superficial and deep retinal VD and: SLE duration, LN duration, SLEDAI-2K, BUN, serum creatinine. Positive correlation was found between creatinine clearance and deep retinal VD, LN duration and FAZ area (Figure 3).
OCTA and biopsy data analysis showed a reduction in superficial and deep retinal circulation in patients with LN-vascular lesions, especially patients with arteriolar hyalinosis showed a reduction in deep retinal VD (Figure 4).
Conclusions
Preliminary results show a correlation between retinal microvascular damage and renal functional-histological alterations, supporting use of OCTA for LN early detection and follow-up.