It is known that the presence of some non- criteria antiphospholipid anibodies (n-c aPL) is connected with thrombosis and pregnancy complications. Some n-c aPL are considered as significant for diagnosis of primary antiphospholipid syndrome (pAPS).
The aim of the study was to determine the prevalence of non-criteria antiphospholipid anibodies in a group of patients with pAPS
The study involved 26 (16 f,10 m) of APS patients (pts) observed for a longterm in a University Clinic. All pts fulfilled the criteria for classification of APS . The mean age of the pts was: 40,81± 13,42 (range 18-66), the duration of the disease was 9,2 ± 8,83 years (range 1-37).
The presence of Ab was detected in patients’ serum using the commercially available tests: aPL-immunodot assay Anti-Phospholipid 10 Dot, for the qualitative detection of IgG or IgM antibodies. Statistical data analysis was performed using Statistica v13.0
N-c aPL were detected relatively often in p APS pts (a-phosphatidylserine IgG 65.4% of pts; a-prothrombin IgM 57,7%). A-prothrombin IgM were detected significantly more often than a a-CL IgM and a a-phosphatydylserin IgG were detected significantly more often than a a-B2GPI IgG.
The clinical symptoms observed in the pts are: thrombosis 69,2%; stroke 30,8%; pulmonary embolism 30,8%; pregnancy complications 26,7%, migraine 26,9%, livedo reticularis 69,2%, infarct 15,4% and seizures 7,7%. Migraine, seizures and pregnancy complications significantly correlated with some n-c aPL.
N-c aPL can be a valuable tool for accurate diagnosis of p APS and my help in making an appropriate decision concerning the treatment