ENTHESITIS AND ITS RELATIONSHIP WITH DISEASE ACTIVITY, FUNCTIONAL STATUS, AND QUALITY OF LIFE IN PATIENTS WITH PSORIATIC ARTHRITIS
- Lyubov D. Vorobyeva (Russian Federation)
Abstract
Background and Aims
Psoriatic arthritis (PsA) is an infammatory arthritis with distinct phenotypic subtypes. Enthesitis is assigned as a hallmark of the disease, given its signifcant relations to disease activity and patient-reported outcomes (PROs). Our aim is to evaluate the prevalence of enthesitis and its association with some clinical parameters, particularly quality of life (QoL) in PsA patients (pts).
Methods
187 (M/F=97 (50.2%)/90(48.8%) PsA pts fulfilling the CASPAR criteria were included. Mean age 45.6±11.7 years (yrs), DAPSA 21.05±21.03, median (Me) PsA duration 88 [16;421] mo. All pts underwent standard clinical examinations and PROs (EQ-5D, PsAID12, HAQ, BASDAI, FACIT-F) Analysis were performed in 2 groups: enthesitis positive (42.3%) and enthesitis negative (57.7%), for assess enthesitis in PsA pts used Leeds Enthesitis Index (LEI), using parametric and non-parametric tests as appropriate.
Results
When 79 (42.3%) patients with enthesopathy and 108 patients (57.7%) without enthesopathy were compared, patients with enthesitis had more disease activity 40.7±23.3 vs 20.9±18.7 respectively). TJC, SJC, VAS, HAQ, BASDAI, PsAID-12 were signifcantly better in pts without enthesitis (p < 0.05 for all). The comparison of clinical parameters of pts with and without enthesitis is given in Table 1. Moreover, significant but weak positive correlations between the LEI score and TJC, DAPSA, BASDAI, and negative correlations with EQ-5D and FACIT-F were found (p < 0.005 for all) (Table 2).
Conclusions
In PsA pts reported that with enthesitis is associated with greater PsA disease activity and worse functional status and QoL.