Kristina Hulten (United States of America)
Baylor College of Medicine
Pediatrics
Kristina G. Hulten, Ph.D., is an Associate Professor of Pediatrics at Baylor College of Medicine in Houston, TX with a joint appointment at the School for Health Professions. She is Director of the Dr. Edward O. Mason, Jr. Pediatric Infectious Disease Research Laboratory at Texas Children’s Hospital. Her main research focus concerns the pathology, antimicrobial susceptibility, epidemiology and molecular epidemiology of Staphylococcus aureus and Streptococcus pneumoniae infections. She is a co-investigator of the U.S. Pediatric Pneumococcal Surveillance Study Group. Her list of publications can be found at https://www.ncbi.nlm.nih.gov/myncbi/1LuR4zlVj7w/bibliography/public/. At Baylor College of Medicine, Dr. Hulten is also involved with Medical School Admissions, basic science classroom instruction, and she is a mentor of trainees ranging from undergraduate and graduate students to pediatric residents and fellows.

Presenter of 1 Presentation

 Conference Calendar

O006 - PNEUMOCOCCAL COMPLICATED OTITIS MEDIA IN CHILDREN LESS THAN 60 MONTHS OF AGE, 2014-2019 (ID 260)

Session Name
0310 - Parallel Session 01: Disease Burden in Infants and Children (ID 23)
Session Type
Parallel Session
Date
Mon, 20.06.2022
Session Time
15:20 - 16:35
Room
Grand Ballroom Centre
Presenter
Lecture Time
16:15 - 16:25

Abstract

Background

Pneumococcal acute otitis media (AOM) in children due to vaccine related serotypes (Sts) declined after pneumococcal conjugate vaccine (PCV) introduction. This study investigates features of complicated pneumococcal OM (cOM; e.g. OM with perforated tympanic membranes (PTM), or complications such as mastoiditis).

Methods

Patients <60 months of age with cOM and pneumococcal isolates available from 2014-2019 from the US Pediatric Multicenter Pneumococcal Surveillance Group were included (2020 cases were analyzed separately). Analyses included demographics, immunization status, antimicrobial susceptibility and St determination. Recurrent OM (rOM) infection was defined as episodes separated by 14 days.

Results

609 encounters of which 41 were mastoiditis were identified from 579 patients; 27 patients had rOM infections within the study period. Median age was 17.3 (range 0-59.7) months. Most isolates were from spontaneous PTM drainage (66.3%) or through PE tubes (28.2%). 31 Sts were identified with 35B representing 19.5% of all isolates. PCV13 vaccine Sts identified were 3 (6.7%), 19F (4.9%), 19A (4.6%), and 6A (0.2%). 71% of mastoiditis cases were associated with PCV13 Sts. All rOM infections were caused by non-PCV13 Sts; 12/27 patients had the same serotype on both encounters. Antibiotic non-susceptibility was most often associated with St 19A (Table, Figure 1). In 2020, the occurrence of cOM declined compared to previous years (Figure 2).

isppd2022 _table.jpgisppd2022 figure 1.jpgisppd2022 figure 2.jpg

Conclusions

Non-PCV13 Sts caused the majority of pneumococcal cOM. rOM infections were commonly caused by different Sts. Further surveillance will determine if the decline of pneumococcal infections in 2020 was temporary and resulted in a shift in St prevalence.

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