University College London
Division of Medicine
Professor Brown is an academic respiratory consultant at University College London where he leads a team investigating the pathogenesis and mechanisms of immunity for the bacterial causes of pneumonia Streptococcus pneumoniae and Acinetobacter baumannii, including the development of novel vaccine approaches. He has investigated phenotypic differences between S. pneumoniae and its closest genetic relative Streptococcus mitis to try and understand why S. pneumoniae is a frequent cause of severe infections whereas S. mitis is a relatively rare cause of significant infections in humans. His clinical practice concentrates on clinical respiratory infection, including bronchiectasis, aspergillosis, and pneumonia in immunocompetent and immunocompromised patients. He is a member of the UK Joint Committee on Vaccination and Immunisation, contributing to national decisions on vaccine policy including the COVID-19, influenza, and S. pneumoniae vaccination programme.

Moderator Of 1 Session

Session Type
Meet-the-Expert Session
Date
Mon, 20.06.2022
Session Time
14:00 - 15:00
Room
Grand Ballroom West
Session Description
In this session we will try to address the question of why S. pneumoniae is a common bacterial pathogen whereas its closest relative S. mitis only rarely causes serious infections, with an emphasis on the role of the capsule.
(1) Describe what we know of the only recently acknowledged capsular serotype overlap between pneumococci and related species in contemporary carriage surveys; discuss potential impact on pneumococcal epidemiology and vaccinology.
(2) Describe and discuss the comparative phenotypes of S. mitis and S. pneumoniae strains expressing capsules of the same serotype.
(3) Further discussion of S. mitis and S. pneumoniae phenotypes relevant for virulence related to genotypic differences.

Please note: All MTE sessions are designed to encourage active learning and to concentrate on close interaction between audience and speakers. The MTE session organisers have provided at least 15 minutes for active discussions in their agenda.

Presenter Of 2 Presentations

Other S. pneumoniae and S. mitis phenotypes and virulence (ID 955)

Session Type
Meet-the-Expert Session
Date
Mon, 20.06.2022
Session Time
14:00 - 15:00
Room
Grand Ballroom West
Lecture Time
14:29 - 14:37

S. pneumoniae and S. mitis capsule phenotypes (ID 954)

Session Type
Meet-the-Expert Session
Date
Mon, 20.06.2022
Session Time
14:00 - 15:00
Room
Grand Ballroom West
Lecture Time
14:21 - 14:29