Neha Mishra, India
King George’s Medical University PediatricsAuthor Of 2 Presentations
CHEST-RADIOGRAPH FINDINGS IN CHILDREN (2-59 MONTHS) HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA, PRIOR TO INTRODUCTION OF PNEUMOCOCCAL CONJUGATE VACCINE IN INDIA- A PROSPECTIVE OBSERVATIONAL STUDY (ID 364)
NASOPHARYNGEAL CARRIAGE OF STREPTOCOCCUS PNEUMONIAE SEROTYPES AMONG HEALTHY CHILDREN IN NORTH INDIA (ID 318)
Abstract
Background
Streptococcus pneumonia (SP) causes morbidity and mortality among children worldwide. India introduced 13-valent pneumococcal conjugate vaccine (PCV-13) in 2017. Current study was conducted to isolate SP from nasopharyngeal (NP) swabs of healthy children and assess changes in serotypes among PCV vaccinated and unvaccinated children.
Methods
Cross-sectional study was conducted (July-August 2019) in Lucknow District, North India. Children (2-59 months) who had no clear illness/hospitalization (last one-month) were recruited from vaccination-clinics of hospitals. After NP specimen collection, bacterial culture was done using 5% sheep agar-blood plate containing gentamicin. Pneumococcal isolates were identified by optochin-sensitivity and bile-solubility. Serotyping was done using Quellung Method
Results
Of 300 children, 56.7%(170/300) were males and 52.0%(156/300) were 2-11 months. Overall SP colonization rate was 37.6% (113/300). Vaccine serotypes isolated were 18C,19A,19F,23F,3,4,6A,6B,9V. Among 60% (181/300) PCV vaccinated, SP positivity was 37.5% (68/181) and vaccine serotype were 39.7% (27/68). Among 40% (119/300) non-PCV vaccinated-children, 37.8%(47/119)had NP colonization positive and PCV-13 serotypes were 37.7%(17/47). Non-Vaccine serotypes were 10A,15A,15B,15C,21,34,35B,22F and similar in vaccinated and unvaccinated children.
Conclusions
About 4 of 10 healthy children had NP colonization with SP and around 40% serotypes were covered by PCV-13. Our preliminary data suggests that SP colonization rate and serotype isolates were similar in vaccinated and unvaccinated children