Claire Von Mollendorf, Australia

Murdoch Children's Research Institute New Vaccines

Presenter of 2 Presentations

 Conference Calendar

CLINICAL CHARACTERISTICS OF ADULT PNEUMONIA CASES IN THE ERA OF CHILDHOOD PCV13 VACCINATION IN MONGOLIA, 2015-2018 (ID 502)

Session Name
Clinical Sciences - Diagnosis
Presenter
Authors

PNEUMOCOCCAL CARRIAGE AND DENSITY IN MONGOLIAN CHILDREN WITH RADIOLOGICALLY-CONFIRMED PNEUMONIA AND HEALTHY CHILDREN FROM THE COMMUNITY. (ID 387)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Author Of 7 Presentations

 Conference Calendar

A DYNAMIC MODEL TO DETERMINE FACTORS REQUIRED FOR ELIMINATION OF VACCINE-TYPE CARRIAGE FOLLOWING PNEUMOCOCCAL CONJUGATE VACCINE INTRODUCTION IN THE ASIA-PACIFIC (ID 850)

Session Name
Population Sciences - Epidemiology, Economics, and Mathematical Modelling
Presenter
Authors

DETERMINING THE PNEUMOCOCCAL CONJUGATE VACCINE COVERAGE REQUIRED FOR INDIRECT PROTECTION IN LAOS, MONGOLIA AND PAPUA NEW GUINEA (ID 851)

Session Name
Population Sciences - Epidemiology, Economics, and Mathematical Modelling
Presenter
Authors

PNEUMOCOCCAL CONJUGATE VACCINE IS EFFECTIVENESS AGAINST HYPOXIC PNEUMONIA IN LAOS, MONGOLIA AND PAPUA NEW GUINEA: A NOVEL CASE-CONTROL VARIANT STUDY (ID 852)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Abstract

Background

We describe a novel approach to determine PCV13 effectiveness (VE) against hypoxic pneumonia in children admitted with pneumonia in Lao PDR (Laos), Mongolia and Papua New Guinea (PNG).

Methods

A 3-5 year prospective hospital-based observational study of children <59 months admitted with pneumonia was undertaken. Pneumonia was defined using the 2013 WHO definition. Hypoxia was defined as an oxygen saturation <90% in room air or requiring oxygen supplementation during hospitalisation. PCV13 status was determined by written record. VE was calculated using logistic regression comparing the odds of hypoxia between vaccinated and undervaccinated pneumonia cases. To handle potential confounders a propensity score (PS) analysis using inverse probability of treatment weighting (IPW) was used. In Laos, multiple imputation (MI) analysis was undertaken for missing data.

Results

The VE against hypoxic pneumonia were: in Laos, unadjusted 23% (95% CI: -9, 46%; p=0·14), PS adjusted IPW 37% (6, 57%; p=0·02), MI adjusted 35% (7, 55%; p=0·02); in Mongolia, unadjusted 33% (26, 40%; p<0.001), PS adjusted IPW 33% (16, 47%; p<0.001); and in PNG, unadjusted 6% (-15, 24%; p=0.532), PS adjusted IPW 36% (17, 51%; p=0.001).

Conclusions

Our novel approach shows that PCV13 is effective against hypoxic pneumonia. PCV13 will contribute to reducing child mortality.

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PNEUMOCOCCAL CARRIAGE AND DENSITY IN MONGOLIAN CHILDREN WITH RADIOLOGICALLY-CONFIRMED PNEUMONIA AND HEALTHY CHILDREN FROM THE COMMUNITY. (ID 387)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

MONITORING PCV13 IMPACT USING NASOPHARYNGEAL CARRIAGE SURVEILLANCE AMONG CHILDREN WITH PNEUMONIA IN MONGOLIA (ID 965)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors

Abstract

Background

In 2015, Mongolia was among the earliest countries in Asia to introduce PCV. To monitor the impact of PCV13 introduction, we commenced nasopharyngeal carriage surveillance among children with pneumonia 6 months prior to vaccine introduction.

Methods

We recruited children 2-59 months of age presenting with pneumonia to district hospitals and the national Maternal and Child Health hospital in two districts in Ulaanbaatar. Clinical and demographic data, vaccination status and nasopharyngeal swabs were collected. A random sample of swabs were selected for testing each month. Samples were examined by lytA qPCR, with positives serotyped by microarray.

Results

We recruited 4980 children and tested 983 children from November 2015 to April 2018. The median age was 1.27 and 25.81% of cases were vaccinated in the first and second year following PCV13 introduction, respectively. 474 and 48.22% had received antibiotics in the 48 hours before admission.

Conclusions

Following PCV13 introduction in Mongolia, the prevalence of pneumococcal carriage remained stable while the prevalence of PCV13-type carriage decreased among children with pneumonia. Reductions in PCV13 carriage likely correspond to reductions in disease due to PCV13 types, since carriage is a precursor for disease.

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CLINICAL CHARACTERISTICS OF ADULT PNEUMONIA CASES IN THE ERA OF CHILDHOOD PCV13 VACCINATION IN MONGOLIA, 2015-2018 (ID 502)

Session Name
Clinical Sciences - Diagnosis
Presenter
Authors

PNEUMOCOCCAL CARRIAGE IN CHILDREN WITH PNEUMONIA IN THREE ASIAN COUNTRIES FOLLOWING VACCINE INTRODUCTION (ID 1082)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
Presenter
Authors