Robinson Pacheco, Colombia

Universidad Libre Seccional Cali. Pediatrics

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Online Abstracts Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults B2 Disease Burden in Infants, Children/Youth, and Adults

FREQUENCY, CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS, AND OUTCOMES OF PRIMARY BACTEREMIA BY STREPTOCOCCUS PNEUMONIAE IN CHILDREN TREATED AT COLOMBIAN TERTIARY CARE CENTERS 2017 - 2019

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B2 Disease Burden in Infants, Children/Youth, and Adults

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FREQUENCY, CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS, AND OUTCOMES OF PRIMARY BACTEREMIA BY STREPTOCOCCUS PNEUMONIAE IN CHILDREN TREATED AT COLOMBIAN TERTIARY CARE CENTERS 2017 - 2019 (ID 280)

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Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults
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Abstract

Background

Invasive pneumococcal disease is a common cause of morbidity and mortality among children, with a case fatality rate of about 8% in children under 5 years. The frequency of primary bacteremia is 20% of the IPD in children under 2 years.

Methods

Observational, descriptive, longitudinal study. Data were obtained from 40 medical records of patients under 18 years diagnosed with bacteremia by pneumococcus and treated in Neumocolombia network hospitals in 2017-2019. A univariate analysis was performed using frequency and bivariate tables with non-parametric Kruskal-Wallis.

Results

60% of the patients were male. Median age was 24 months (IQR 10 - 48). 52% of the patients were under the age of 2; lethality was 10% and immunization with PCV was 10 50%. The most frequent serotype was 19A, followed by 23B, and 25A(20%, 7.5% and 5.0%, respectively). Resistance to erythromycin was 37.5%, to clindamycin 32.5%, penicillin 22.5% and ceftriaxone 15%. 30% of the children were admitted to the ICU. The average hospital stay was 11 days, and 2.5 days in the ICU.

Conclusions

Primary bacteremia by S. pneumoniae in Colombia has a 10% case fatality rate in children under 2 years, the most frequent serotype being 19A. Penicillin resistance was found in 22.5%.

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