Hamide Hatami, Iran
Mardom hospital MidwiferyAuthor Of 1 Presentation
PNEUMOCOCCAL VACCINE IN RENAL TRANSPLANT :DISTANCE OF GUIDELINES FROM REALITY (ID 10)
Abstract
Background
Pneumococc vaccine is effective and safe but vaccine immunogenicity is a challenging matter in renal transplantation and accessible guidelines suggest pneumococcal revaccination every 3–5 year intervals .This study judge guideline based on reality .
Methods
Articles related to pneumococc vaccine in renal transplant was evaluated from 1996 -2019 .
Results
Most accessible studies followed small selective healthier cases for short period time ,they showed persistence of immunogenicity with PPSV23 vaccination in hemodiyalisis and renal transplant after 1 year is same (43%) ,the vaccnes cover half of pneumococc serotypes , not same for all types (6B type :12% , 19F :27% ), while the revaccination with the newer vaccine (PPSV23) was less effective than the first immunization that produce a significant immune response followed by rapid decline of immunity, there is not also difference in immunogenicity of PCV7 versus PPV23 at 8th week postvaccination
Conclusions
Pneumococcal vaccine immunogenicity appearance and duration in renal transplantation is not compatible with guidelines recommendations , immunogenicity decrease after first year dramatically in spite of using newer generation and booster doses ,we are face to questions such as the best time of installation,how can enhance immunogenicity and the best vaccine type that we can use .