Mohammad Shahidul Islam, Bangladesh
Child Health Research Foundation MicrobiologyPresenter of 1 Presentation
STREPTOCOCCUS PNEUMONIAE COLONIZATION INCREASES THE RISK OF RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION IN YOUNG INFANTS: DATA FROM A MULTICENTER POPULATION-BASED (ANISA) STUDY (ID 1039)
Abstract
Background
Interaction of Streptococcus pneumoniae and viruses in the nasopharynx is a known phenomenon. We have explored the possible role of pneumococcus colonization on Respiratory Syncytial Virus (RSV) infection.
Methods
Newborns from Bangladesh, India, and Pakistan were enrolled and followed until the age of 60 days through household visits. Sick infants were referred to the study hospital where study physicians collected nasopharyngeal swabs. Pneumococcus and RSV were detected using the Real-time Polymerase Chain Reaction technique.
Results
Between 2011 and 2014, study physicians collected nasopharyngeal specimens from 5,209 episodes of suspected sepsis cases. Pneumococcus was detected from 35.3% (1,843/5,209) and RSV from 7.7% (402/5209) specimens. RSV was detected among 14.3% cases where pneumococcus was colonized (264/1,843), a contrast to 4.1% (138/3,366) among pneumococcus negative cases. The risk of RSV infection among the children with pneumococcal colonization was 4.6 times higher (95% CI: 3.8-5.5) compared to the infants who were not colonized by pneumococcus.
Conclusions
The study showed a direct relation of pneumococcal colonization with RSV infection in young infants. It is important to do further studies in this regard to understand the interaction of pneumococcus and RSV and the possible role of specific pneumococcal serotypes.
Author Of 1 Presentation
STREPTOCOCCUS PNEUMONIAE COLONIZATION INCREASES THE RISK OF RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION IN YOUNG INFANTS: DATA FROM A MULTICENTER POPULATION-BASED (ANISA) STUDY (ID 1039)
Abstract
Background
Interaction of Streptococcus pneumoniae and viruses in the nasopharynx is a known phenomenon. We have explored the possible role of pneumococcus colonization on Respiratory Syncytial Virus (RSV) infection.
Methods
Newborns from Bangladesh, India, and Pakistan were enrolled and followed until the age of 60 days through household visits. Sick infants were referred to the study hospital where study physicians collected nasopharyngeal swabs. Pneumococcus and RSV were detected using the Real-time Polymerase Chain Reaction technique.
Results
Between 2011 and 2014, study physicians collected nasopharyngeal specimens from 5,209 episodes of suspected sepsis cases. Pneumococcus was detected from 35.3% (1,843/5,209) and RSV from 7.7% (402/5209) specimens. RSV was detected among 14.3% cases where pneumococcus was colonized (264/1,843), a contrast to 4.1% (138/3,366) among pneumococcus negative cases. The risk of RSV infection among the children with pneumococcal colonization was 4.6 times higher (95% CI: 3.8-5.5) compared to the infants who were not colonized by pneumococcus.
Conclusions
The study showed a direct relation of pneumococcal colonization with RSV infection in young infants. It is important to do further studies in this regard to understand the interaction of pneumococcus and RSV and the possible role of specific pneumococcal serotypes.