Zahin Amin-Chowdhury,
Author Of 1 Presentation
CASE FATALITY RATES ASSOCIATED WITH INVASIVE PNEUMOCOCCAL DISEASE DECLINED AFTER PCV13 IMPLEMENTATION IN ENGLAND (ID 1018)
Abstract
Background
The serotypes causing invasive pneumococcal disease (IPD) have changed significantly since the introduction of the 7-valent (PCV7) and 13-valent (PCV13) pneumococcal conjugate vaccines (PCV) in England. Since case fatality rate (CFR) varies across different pneumococcal serotypes, we analysed trends in deaths and CFR before and after implementation of the two PCV programmes in England
Methods
Public Health England conducts enhanced IPD surveillance in England. Cases and deaths occurring within 7 days of IPD diagnosis were used to calculate CFR during 2002/03-2018/19.
Results
The number of IPD deaths increased from 744 in 2005/16 just before PCV7 was implemented and peaked at 756 in 2009/10 just before PCV13 replaced PCV7 and then declined to 450 cases in 2013/14, when IPD cases were also at their lowest. Since then, IPD cases and deaths increased and peaked in 2018/19 before declining in 2018/19. CFR trends followed IPD deaths until 2008/09 peaking at 14.4% and then gradually declined to 9.9% in 2018/19. This was because the replacing serotypes after PCV13 implementation, especially serotypes 8 and 12F, were associated with lower age-adjusted CFR compared to PCV13 serotypes.
Conclusions
CFR declined only after PCV13 replaced PCV7 in 2010. The current replacing serotypes are associated with lower CFR than PCV13 serotypes.