Raymond Reid,
Author Of 1 Presentation
CHARACTERIZATION OF STREPTOCOCCUS PNEUMONIAE SEROTYPE 3 CARRIAGE AND DISEASE ISOLATES AMONG NATIVE AMERICANS IN THE SOUTHWEST UNITED STATES (ID 1020)
- Eleonora Cella, United States of America
- Lindsay R. Grant, United States of America
- Robert C. Weatherholtz, United States of America
- Raymond Reid,
- Kamellia Kellywood,
- Angelina Reid,
- Mathuram Santosham, United States of America
- Katherine L. O'Brien, United States of America
- Taj Azarian, United States of America
- Laura L. Hammitt, United States of America
Abstract
Background
Despite inclusion in PCV13, Streptococcus pneumoniae serotype 3 (ST3) continues to cause significant morbidity and mortality. In Native American communities in the southwest US in 2015-2017, the ST3 carriage prevalence among children was 2.7% and the incidence of ST3 invasive pneumococcal disease (IPD) among adults was 9.0/100,000. An emerging lineage of ST3 belonging to Clonal Complex (CC) 180, termed clade II, has recently increased.
Methods
We analyzed the genomic epidemiology of 202 ST3 isolates collected from 133 adults and 69 children with carriage (n=71) or IPD (n=131) from 1999–2018. Using phylogenetics based on whole-genome sequencing data, we determined clade membership of each isolate and assessed how the population structure changed over time.
Results
The percent of isolates belonging to clade II increased from 22.3% (n=94) in 1999-2010 to 65.7% (n=108) in 2010-2018 (Figure A). Carriage isolates were comprised equally by three clades (CC180 clade Ia n=24 and II n=23 and non-CC180 n=24); however, IPD isolates were more likely to be clade II (1a n=37, II n=69, non-CC180 n=25; OR=2.32, 95% CI 1.27-4.25) (Figure B).
Conclusions
Overall, we find that ST3 clade II has increased significantly since the introduction of PCV13 and is found more commonly in invasive disease compared to other clades.