Sadia Shakoor,

Poster Author Of 1 e-Poster

Online Abstracts Vaccines - Impact of Vaccine programs and Serotype Replacement C2 Impact of Vaccine programs and Serotype Replacement

Author Of 1 Presentation

INTRODUCTION OF TEN VALENT PNEUMOCOCCAL VACCINE IMPARTS INDIRECT PROTECTION TO CHILDREN IN A RURAL POPULATION IN PAKISTAN (ID 978)

Abstract

Background

Ten-valent pneumococcal vaccine was introduced in Pakistan’s immunization program in 2012 as 3+0 schedule without catchup immunization.

Methods

From 2014 to 2018, children were randomly selected from a line listing in two union councils of Matiari, Pakistan. Nasopharyngeal swabs were collected using standard WHO guidelines and processed at Infectious Disease Research Laboratory at Aga Khan University in Karachi. Serotypes for pneumococcal isolates were deduced using published sequential multiplex PCR assays.

Results

Of 3140 children enrolled, pneumococcal isolates were detected in 2370(75%). VT carriage decreased from 11.4 to 8.2 % (p-value=0·031) in vaccinated group and from 19.3 to 12.7% (p-value= 0·003) in non-vaccinated group. On average VT carriage decreased from 16·1% to 9·6% (p-value<0·001). Most significant decline was seen in serotypes 6B, 9V/9A and 19F. Proportion of fully immunized children changed from 41·0% to 68·4% (p-value<0·001). Direct effect of the vaccine was calculated to be 33·5% (95% CI 19·5%-55·0%) and indirect effect to be 44·1% (95% CI 28·1% -56·6%).

indirect.jpg

carriage rates.jpg

Conclusions

We saw substantial decline in pneumococcal carriage in young children in a rural community which was seen in both vaccinated and unvaccinated groups. This is indicative of herd immunity and will hopefully translate to decrease in pneumococcal disease burden in population.

Hide