Richard Adegbola,
Author Of 2 Presentations
SPATIAL DISTANCE IS A KEY DETERMINANT OF PNEUMOCOCCAL STRAIN SHARING AND THE SUSTAINED CARRIAGE OF SHARED STRAINS (ID 957)
- Madikay Senghore, United States of America
- Chrispin Chaguza, United Kingdom
- Ebrima Bojang,
- Peggy-Estelle Tientcheu,
- Rowan Bancroft, Côte d'Ivoire
- Stephanie Lo, United Kingdom
- Rebecca Gladstone, Norway
- Lesley McGee, United States of America
- Archibald Worwui,
- Ebenezer Foster-Nyarko,
- Fatima Ceesay,
- Catherine Okoi,
- Keith P. Klugman, United States of America
- Robert F Breiman, United States of America
- Richard Adegbola,
- Stephen D. Bentley, United Kingdom
- William Hanage, United States of America
- Martin Antonio, Gambia
- Brenda Kwambana-Adams, United Kingdom
ACQUISITION AND CLEARANCE OF PNEUMOCOCCAL SEROTYPES IN NATURALLY-COLONISED PCV-EXPOSED GAMBIAN INFANTS (ID 990)
- Chrispin Chaguza, United Kingdom
- Madikay Senghore, United States of America
- Rebecca Gladstone, Norway
- Stephanie Lo, United Kingdom
- Peggy-Estelle Tientcheu,
- Archibald Worwui,
- Ebenezer Foster-Nyarko,
- Fatima Ceesay,
- Catherine Okoi,
- Michael Barer,
- Richard Adegbola,
- Lesley McGee, United States of America
- Keith P. Klugman, United States of America
- Robert F Breiman, United States of America
- Robert S. Heyderman, United Kingdom
- Martin Antonio, Gambia
- Stephen D. Bentley, United Kingdom
- Brenda Kwambana-Adams, United Kingdom
Abstract
Background
Pneumococcal carriage influences population-wide strain dynamics, but limited data exist on serotype-specific temporal carriage patterns among PCV-vaccinated West African infants.
Methods
Pneumococcus was cultured from nasopharyngeal swabs (n=1, 595) collected from 102 PCV7-exposed infants followed up from birth to 12 months. Serotyping was performed by whole genome sequencing and sweep-latex agglutination. Parametric survival models with constant hazard rates were fitted to estimate carriage dynamics (duration, clearance and acquisition).
Results
The infants were naturally colonised with 60 pneumococcal serotypes with a mean of 7 (range:2-11) serotypes per infant. Carriage dynamics estimates for serotypes 5, 7F, 39, 9A, and 12F are provided here for the first time in infants. There was no correlation between time to first acquisition and carriage duration (ρ=0.06, P=0.709). Serotype prevalence showed a weak correlation with initial acquisition (ρ=0.07, P=0.706), carriage duration (ρ=0.219, P=0.194), and reacquisition times (ρ=0.09, P=0.730). Onset of initial acquisition was longer than the time taken to reacquire serotypes (median: 136.23 vs 26.15 days, P=7.63×10-6). Overall, serotype-specific carriage durations after initial acquisition and reacquisition were significantly different (P=0.020), varying by serotype.
Conclusions
Pneumococcal carriage dynamics among Gambian infants are complex and highly variable by serotype which may have important implications for transmission and invasive disease.