Eleanor F. Neal, Australia
Murdoch Children's Research Institute Asia-Pacific HealthPoster Author Of 1 e-Poster
FACTORS ASSOCIATED WITH PNEUMOCOCCAL CARRIAGE IN CHILDREN AND ADULTS IN FIJI, USING FOUR CROSS-SECTIONAL SURVEYS
- Eleanor F. Neal, Australia
- Cattram D. Nguyen, Australia
- Felista T. Ratu, Fiji
- Eileen M. Dunne, United States of America
- Lisi Tikoduadua, Fiji
- Mike Kama, Fiji
- Belinda D. Ortika, Australia
- Laura K. Boelsen, Australia
- Joseph Kado, Australia
- Rachel Devi, Fiji
- Evelyn Tuivaga, Fiji
- Rita C. Reyburn, Australia
- Catherine Satzke, Australia
- Eric Rafai, Fiji
- Kim E. Mulholland, Australia
- Fiona M. Russell, Australia
Presenter of 2 Presentations
FACTORS ASSOCIATED WITH PNEUMOCOCCAL NASOPHARYNGEAL CARRIAGE: A SYSTEMATIC REVIEW (ID 389)
FACTORS ASSOCIATED WITH PNEUMOCOCCAL CARRIAGE IN CHILDREN AND ADULTS IN FIJI, USING FOUR CROSS-SECTIONAL SURVEYS (ID 224)
- Eleanor F. Neal, Australia
- Cattram D. Nguyen, Australia
- Felista T. Ratu, Fiji
- Eileen M. Dunne, United States of America
- Lisi Tikoduadua, Fiji
- Mike Kama, Fiji
- Belinda D. Ortika, Australia
- Laura K. Boelsen, Australia
- Joseph Kado, Australia
- Rachel Devi, Fiji
- Evelyn Tuivaga, Fiji
- Rita C. Reyburn, Australia
- Catherine Satzke, Australia
- Eric Rafai, Fiji
- Kim E. Mulholland, Australia
- Fiona M. Russell, Australia
Abstract
Background
We describe factors associated with pneumococcal nasopharyngeal carriage in Fiji, using data from annual (2012-2015) cross-sectional surveys, pre- and post-introduction of ten-valent pneumococcal conjugate vaccine (PCV10).
Methods
Infants (5-8 weeks), toddlers (12-23 months), children (2-6 years), and their caregivers participated. Pneumococci were detected using lytA qPCR, with molecular serotyping by microarray. We used logistic regression to determine predictors of pneumococcal carriage.
Results
There were 8,109 participants. Pneumococcal carriage was associated with: years post-PCV10 introduction (global P<0.001), indigenous iTaukei ethnicity (aOR 2.74 [95% CI 2.17-3.45] P<0.001); young age (global P<0.001); urban residence (aOR 1.45 [95% CI 1.30-2.57] P<0.001); living with >2 children <5 years (aOR 1.42 [95% CI 1.27-1.59] P<0.001); poverty (aOR 1.44 [95% CI 1.28-1.62] P<0.001); and upper respiratory tract infection symptoms (aOR 1.77 [95% CI 1.57-2.01] P<0.001). Factors associated with PCV10 and non-PCV10 carriage were similar to those associated with overall carriage. Additionally, PCV10 carriage was associated with PCV10 vaccination (0.58 [95% CI 0.41-0.82] P=0.002) and cigarette smoke exposure (aOR 1.21 [95% CI 1.02-1.43] P=0.031, while non-PCV10 carriage was not associated with years post-PCV10 introduction.
Conclusions
Introduction of PCV10 reduced the odds of overall and PCV10 pneumococcal carriage in Fiji. Indigenous iTaukei ethnicity was positively associated with carriage after adjustment for PCV10.
Author Of 3 Presentations
FACTORS ASSOCIATED WITH PNEUMOCOCCAL CARRIAGE IN CHILDREN AND ADULTS IN FIJI, USING FOUR CROSS-SECTIONAL SURVEYS (ID 224)
- Eleanor F. Neal, Australia
- Cattram D. Nguyen, Australia
- Felista T. Ratu, Fiji
- Eileen M. Dunne, United States of America
- Lisi Tikoduadua, Fiji
- Mike Kama, Fiji
- Belinda D. Ortika, Australia
- Laura K. Boelsen, Australia
- Joseph Kado, Australia
- Rachel Devi, Fiji
- Evelyn Tuivaga, Fiji
- Rita C. Reyburn, Australia
- Catherine Satzke, Australia
- Eric Rafai, Fiji
- Kim E. Mulholland, Australia
- Fiona M. Russell, Australia
Abstract
Background
We describe factors associated with pneumococcal nasopharyngeal carriage in Fiji, using data from annual (2012-2015) cross-sectional surveys, pre- and post-introduction of ten-valent pneumococcal conjugate vaccine (PCV10).
Methods
Infants (5-8 weeks), toddlers (12-23 months), children (2-6 years), and their caregivers participated. Pneumococci were detected using lytA qPCR, with molecular serotyping by microarray. We used logistic regression to determine predictors of pneumococcal carriage.
Results
There were 8,109 participants. Pneumococcal carriage was associated with: years post-PCV10 introduction (global P<0.001), indigenous iTaukei ethnicity (aOR 2.74 [95% CI 2.17-3.45] P<0.001); young age (global P<0.001); urban residence (aOR 1.45 [95% CI 1.30-2.57] P<0.001); living with >2 children <5 years (aOR 1.42 [95% CI 1.27-1.59] P<0.001); poverty (aOR 1.44 [95% CI 1.28-1.62] P<0.001); and upper respiratory tract infection symptoms (aOR 1.77 [95% CI 1.57-2.01] P<0.001). Factors associated with PCV10 and non-PCV10 carriage were similar to those associated with overall carriage. Additionally, PCV10 carriage was associated with PCV10 vaccination (0.58 [95% CI 0.41-0.82] P=0.002) and cigarette smoke exposure (aOR 1.21 [95% CI 1.02-1.43] P=0.031, while non-PCV10 carriage was not associated with years post-PCV10 introduction.
Conclusions
Introduction of PCV10 reduced the odds of overall and PCV10 pneumococcal carriage in Fiji. Indigenous iTaukei ethnicity was positively associated with carriage after adjustment for PCV10.
FACTORS ASSOCIATED WITH PNEUMOCOCCAL NASOPHARYNGEAL CARRIAGE: A SYSTEMATIC REVIEW (ID 389)
PNEUMOCOCCAL CARRIAGE PRE- AND POST- PCV: A SYSTEMATIC REVIEW (ID 431)
- Nicole Wong, Australia
- Eleanor F. Neal, Australia
- Sam Clifford, United Kingdom
- Belinda D. Ortika, Australia
- Kyla Hayford, United States of America
- Shereen Labib, Australia
- Julia Bennett, United States of America
- Maria D. Knoll, United States of America
- Stefan Flasche, United Kingdom
- Fiona M. Russell, Australia