Luis Jodar, United States of America

Pfizer Inc Medical Development Scientific and Clinical Affairs

Author Of 9 Presentations

 Conference Calendar

COMMUNITY ONSET PNEUMONIA INCIDENCE IN ADULTS 18 YEARS AND OLDER IN GOTO ISLAND, JAPAN. INTERIM RESULTS FROM A POPULATION BASED PROSPECTIVE STUDY (ID 596)

Session Name
Vaccines - Impact of Vaccine programs and Serotype Replacement
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Authors

S. PNEUMONIAE SEROTYPES IN HOSPITALIZED PATIENTS WITH SEVERE PNEUMOCOCCAL PNEUMONIA AND CLINICAL FAILURE (ID 807)

Session Name
Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults
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Authors

SEROTYPE AND ANTIMICROBIAL CHARACTERISTICS OF STREPTOCOCCUS PNEUMONIAE ISOLATES OBTAINED FROM JAPANESE ADULT PATIENTS WITH COMMUNITY ONSET PNEUMONIA (COP) IN GOTO ISLAND, JAPAN (ID 611)

Session Name
Basic Sciences - Conventional and Molecular Microbiology
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Authors

IMPACT OF MICROBIOLOGICAL WORKUP ON THE INCIDENCE OF HOSPITALIZATIONS DUE TO PNEUMOCOCCAL PNEUMONIA (ID 809)

Session Name
Clinical Sciences - Diagnosis
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Authors

EARLY AND LATE MORTALITY OF ADULTS HOSPITALIZED WITH PNEUMOCOCCAL PNEUMONIA IN THE UNITED STATES (ID 797)

Session Name
Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults
Presenter
Authors

Abstract

Background

The number of deaths due to pneumococcal pneumonia (PP) in the United States (U.S.) is not well defined. The objectives of this study were to define mortality of PP in the city of Louisville, Kentucky and to estimate the number of deaths in hospitalized patients with PP in the U.S.

Methods

In hospitalized patients with community-acquired pneumonia (CAP), urinary antigen detection of 24 S. pneumoniae serotypes (UAD-24) was performed. This UAD-24 study was nested in a prospective population-based cohort study of all adult residents in Louisville, hospitalized with CAP from 6/1/14 to 5/31/16. Louisville PP mortality was evaluated early (during hospitalization and at 30-days after hospitalization) and late (6-months and 1-year after hospitalization) and US number of deaths were estimated.

Results

A total of 708 patients with PP were evaluated. PP mortality was 3.7% during hospitalization, 8.2% at 30-days, 17.6% at 6-months, and 25.4% at 1-year. Number of deaths in the U.S. were: 8,323 (95%CI:5,468-12,091) during hospitalization, 18,619 (95%CI:14,231-23,711) at 30-days, 39,807 (95%CI:33,506-46,502) at 6 months, and 57,626 (95%CI:50,130-64,940) at 1-year.

Conclusions

In hospitalized patients, PP is associated with significant early and late mortality. Approximately 1 out of 4 hospitalized adult patients with PP will die within 1-year.

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STREPTOCOCCUS PNEUMONIAE SEROTYPE DISTRIBUTION AND COVERAGE OF PNEUMOCOCCAL CONJUGATE VACCINES IN ADULTS HOSPITALIZED WITH COMMUNITY-ACQUIRED PNEUMONIA IN THE UNITED STATES (ID 879)

Session Name
Population Sciences - Epidemiology, Economics, and Mathematical Modelling
Presenter
Authors

Abstract

Background

The study objective was to determine the prevalence of serotypes and coverage provided by currently licensed and next generation pneumococcal conjugate vaccines (PCVs) in adults hospitalized with community-acquired pneumonia (CAP) in the United States.

Methods

Hospitalized adults aged ≥18 years with radiologically-confirmed (CXR+) CAP were enrolled from 10 U.S. cities between October 2013 and September 2016. S. pneumoniae isolates cultured from normally-sterile standard-of-care specimens were serotyped by Quellung. Urine was tested using BinaxNOW® and a serotype-specific urine antigen detection (UAD) assay that detects serotypes contained in PCV13 plus 6C (highly-related to 6A), PCV15 (PCV13 serotypes, 22F, and 33F), PCV20 (PCV15 serotypes, 8, 10A, 11A, 12F, and 15B plus 15C (highly-related to 15B)), and non-PCV serotypes 2, 9N, 17F, and 20. Coverage was calculated as the percent of CXR+CAP participants positive for a serotype in PCV13, PCV15, and PCV20.

Results

Of 15,572 enrolled participants, 12,055 with CXR+CAP were included in the analysis; 52.7% (n=6347) were ≥65 years. Coverage of CXR+CAP varied by PCV formulation (Table). About 1% of CXR+CAP was due to serotypes 2, 9N, 17F, and 20 combined.

b1851147_uad2 isppd2020 table_2020.0108.docx.png

Conclusions

Compared to PCV13, PCV20 increased coverage of CXR+CAP due to PCV serotypes by 71% (18-64 years) and 64% (≥65 years).

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LOW-INCOME LEVEL IS ASSOCIATED WITH HOSPITALIZATION DUE TO PNEUMOCOCCAL PNEUMONIA (ID 800)

Session Name
Population Sciences - Epidemiology, Economics, and Mathematical Modelling
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ANNUAL NUMBER OF ADULTS HOSPITALIZED WITH PNEUMOCOCCAL PNEUMONIA IN THE UNITED STATES (ID 473)

Session Name
Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults
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Authors

ASSOCIATION OF S. PNEUMONIAE SEROTYPES WITH MYOCARDIAL INFARCTION AND OTHER CARDIAC EVENTS IN HOSPITALIZED PATIENTS WITH PNEUMOCOCCAL PNEUMONIA (ID 805)

Session Name
Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults
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Authors