Antonio Scamarcia, Italy

Pedianet Project

Poster Author Of 2 e-Posters

Online Abstracts Population Sciences - Epidemiology, Economics, and Mathematical Modelling D1 Epidemiology, Economics, and Mathematical Modelling
Online Abstracts Population Sciences - Epidemiology, Economics, and Mathematical Modelling D1 Epidemiology, Economics, and Mathematical Modelling

Author Of 2 Presentations

A RETROSPECTIVE DATABASE ANALYSIS TO ESTIMATE THE BURDEN OF PNEUMONIA IN CHILDREN (ID 782)

Abstract

Background

Streptococcus pneumoniae is a leading cause of bacterial pneumonia in children. This analysis assessed pneumonia incidence rates (IRs) and expenditures following PCV13 introduction in 2010 in Veneto.

Methods

Outpatient pneumococcal and unspecified pneumonia episodes in children <15 years in the Veneto Region were identified in the Pedianet database from 2010-2017. IRs were numbers of episodes/1,000 person-years. Interrupted time series (ITS) analysis were conducted to assess trends in annual IRs in the early and late PCV13 (2010-2013, 2014-2017) periods.

Results

Incidence was higher in children 2-4 years, compared to children <2 and 5-14 years. IRs declined from 14/1,000 person-years in 2010 to 5/1,000 person-years in 2017 in the total cohort.

In ITS analysis, a significant downward trend was detected in the late PCV13 period (p =0.0027) with rates declining by 2.8% annually in children under 15 years. Mann-Kendall test showed a significant negative correlation over the analysis period (coef=-0.64, p=0.026). Similar results were found for children 2-4 and 5-14 years but not in children < 2 years.

Total regional expenditures declined from €472,573 in 2010 to €157,865 in 2017.

Conclusions

Results demonstrate a decrease in outpatient pneumonia incidence and regional expenditures in children <15 years after PCV13 introduction with greater benefits in older children.

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A RETROSPECTIVE DATABASE ANALYSIS TO ESTIMATE THE BURDEN OF INVASIVE PNEUMOCOCCAL DISEASE AND UNSPECIFIED INVASIVE DISEASE IN CHILDREN (ID 788)

Abstract

Background

Invasive pneumococcal disease (IPD) is associated with high mortality and healthcare utilization. This analysis assessed IPD and unspecified invasive disease incidence rates (IRs) following PCV13 introduction in 2010 in Veneto.

Methods

IPD and unspecified invasive disease episodes in children <15 years in the Veneto region were identified in the Pedianet database from 2010-2017. IPD and unspecified invasive disease included pneumococcal and unspecified bacteremia, meningitis and septicemia. IRs were numbers of episodes/100,000 person-years. Interrupted time series (ITS) analyses assessed trends in annual IRs in the early and late PCV13 (2010-2013, 2014-2017) periods.

Results

We identified 81 episodes of IPD and unspecified invasive disease over the analysis period of which 94% were associated with non-specific codes.

IPD and unspecified invasive disease incidence decreased from 40/100,000 person-years (95% CI: 17-63/100,000 person-years) in 2010 to 31/100,000 person-years (95% CI: 6-56/100,000 person-years) in 2017 in children <15 years. While incidence was numerically lower in 2017 than in 2010, ITS analysis did not detect a significant trend in the early (coef=1.97; p=0.63) or late PCV13 (coef=0.50; p=0.90) periods.

Conclusions

Results did not show a significant decrease in IPD and unspecified invasive disease incidence in children <15 years after PCV13 introduction in Veneto.

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