Richard Pebody, United Kingdom

Public Health England Immunisation and Countermeasures Division

Author Of 1 Presentation

EFFECTIVENESS OF INFLUENZA VACCINATION AGAINST INVASIVE PNEUMOCOCCAL DISEASE IN THE ELDERLY ≥65 YEARS ELIGIBLE FOR VACCINATION IN ENGLAND AND WALES (ID 553)

Abstract

Background

The clinical and epidemiological studies conducted during the 1918 pandemic brought new evidence, with Influenza viruses recognised to induce Pneumonia and favour bacterial co-infections and secondary bacterial infections. Therefore, Influenza vaccination may protect against Pneumococcal outcomes by reducing the risk of influenza infection.

Methods

Screening method is used to measure VE. IPD cases were extracted from surveillance database with information on serotype, specimen date, age, clinical conditions, sex, PPV23 and Influenza vaccination dates. Influenza vaccine coverage was extracted from RCGP and matched to IPD cases based on age group (65-74, 75-84, ≥ 85), risk group, PPV23 vaccination, and weeks. The study period was September 2015 to June 2016.

Results

Overall crude Flu VE against IPD was 45% (39, 50). Matching IPD with RCGP proportion vaccinated, overall adjusted VE was 27% (19, 34) in 65+, 26% (14, 38) in 65-74 and 75-84, 28% (14, 40) in 85+ years old. Stratifying by time, VE was 24% (13-33) in January – April and 24% (00-42) in May - June.

Conclusions

Since VE against Influenza was 29% overall and 56% against H1N1 in the elderly in 2015/16 in UK, a very strong association between Influenza and IPD would be needed to have a 27% VE against IPD.

Hide