Pratistha Maskey, Nepal
Patan Academy of Health Sciences- Patan Hospital Paediatric Research UnitPresenter of 1 Presentation
NASOPHARYNGEAL CARRIAGE PREVALENCE OF SEROTYPES 3, 6A, 19A AND 6C IN NEPALESE CHILDREN: IS IT TIME TO SWITCH FROM PCV10 TO A DIFFERENT PCV? (ID 528)
- Pratistha Maskey, Nepal
- Meeru Gurung, Nepal
- Sanjeev M. Bijukchhe, Nepal
- Peter J. O'Reilly, United Kingdom
- Himang M. Maskey, Nepal
- Subhash Shrestha, Nepal
- Stephen Thorson, Nepal
- Madhav C. Gautam, Nepal
- Bhishma Pokhrel, Nepal
- Ganesh Shah, Nepal
- Imran Ansari, Nepal
- Sarah Kelly, United Kingdom
- Merryn Voysey, United Kingdom
- Maria Deloria Knoll, United States of America
- Dominic Kelly, United Kingdom
- David Murdoch, New Zealand
- Andrew J. Pollard, United Kingdom
- Shrijana Shrestha, Nepal
Author Of 6 Presentations
IMPACT OF PCV10 IN NEPAL ON NASOPHARYNGEAL CARRIAGE OF PNEUMOCOCCUS IN YOUNG INFANTS PRIOR TO THEIR VACCINATION (ID 530)
- Subhash Shrestha, Nepal
- Meeru Gurung, Nepal
- Brian Wahl, United States of America
- Sanjeev M. Bijukchhe, Nepal
- Peter J. O'Reilly, United Kingdom
- Pratistha Maskey, Nepal
- Himang M. Maskey, Nepal
- Madhav C. Gautam, Nepal
- Stephen Thorson, Nepal
- Bhishma Pokhrel, Nepal
- Ganesh Shah, Nepal
- Imran Ansari, Nepal
- Sarah Kelly, United Kingdom
- Merryn Voysey, United Kingdom
- Maria D. Knoll, United States of America
- Dominic Kelly, United Kingdom
- David Murdoch, New Zealand
- Andrew J. Pollard, United Kingdom
- Shrijana Shrestha, Nepal
IMPACT OF PCV10 INTRODUCTION ON NASOPHARYNGEAL CARRIAGE OF STREPTOCOCCUS PNEUMONIAE IN HEALTHY CHILDREN IN RURAL AND URBAN NEPAL (ID 531)
- Madhav Chandra Gautam, Nepal
- Sonu Shrestha, United Kingdom
- Sanjeev M. Bijukchhe, Nepal
- Meeru Gurung, Nepal
- Bhishma Pokhrel, Nepal
- Merryn Voysey, United Kingdom
- Peter J. O'Reilly, United Kingdom
- Sarah Kelly, United Kingdom
- Ganesh Shah, Nepal
- Laxmi Lama, Nepal
- Pratistha Maskey, Nepal
- Stephen Thorson, Nepal
- David Murdoch, New Zealand
- Maria Deloria Knoll, United States of America
- Dominic Kelly, United Kingdom
- Shrijana Shrestha, Nepal
- Andrew J. Pollard, United Kingdom
Abstract
Background
The ten-valent pneumococcal conjugate vaccine (PCV10) was introduced in Nepal in 2015. We compared the nasopharyngeal carriage of PCV10 and non-PCV10 serotypes of pneumococcus between pre-vaccine (2015) and post-vaccine (2017-2018) years in two different regions of Nepal.
Methods
Nasopharyngeal samples obtained in healthy Nepalese children aged 6-59 months in urban (Patan, Kathmandu) and 6-23 months in rural (Okhaldhunga) settings were transported in STGG (Skim Milk-Tryptone-Glucose-Glycerol) media, cultured for pneumococcus and serotyped by the Quellung method.
Results
The carriage prevalence decreased for all PCV10-type serotypes except 7F in both the settings. PCV10-type prevalence decreased from 29.7% in rural and 17.2% in urban children pre-vaccine to 9.0% and 8.6% post-vaccine, respectively. Pre-vaccine, the most frequently found serotypes in both settings were 19F, 6B, 14. Post-vaccine, the non-PCV10 serotypes were more common; serotypes 34, 6C, 19A and 15B were most common in rural and 6A, 34, 11A, 6C and 15B in urban settings.
Conclusions
Since the introduction of PCV10, carriage prevalence of PCV10 serotypes have reduced and non-PCV10 serotypes have increased in both settings raising the possibility of replacement disease. Continued monitoring of changes in PCV10-serotypes and non-PCV10 serotypes, especially those covered by PCV13, is important to assess vaccine impact.
IMPACT OF NUMBER OF CHILDREN IN THE HOUSEHOLD ON NASOPHARYNGEAL CARRIAGE OF STREPTOCOCCUS PNEUMONIAE IN HEALTHY NEPALESE CHILDREN (ID 534)
- Himang M. Maskey, Nepal
- Meeru Gurung, Nepal
- Sanjeev M. Bijukchhe, Nepal
- Peter J. O'Reilly, United Kingdom
- Pratistha Maskey, Nepal
- Subhash Shrestha, Nepal
- Madhav C. Gautam, Nepal
- Stephen Thorson, Nepal
- Bhishma Pokhrel, Nepal
- Ganesh Shah, Nepal
- Imran Ansari, Nepal
- Sarah Kelly, United Kingdom
- Merryn Voysey, United Kingdom
- Maria Deloria Knoll, United States of America
- Dominic Kelly, United Kingdom
- David Murdoch, New Zealand
- Andrew J. Pollard, United Kingdom
- Shrijana Shrestha, Nepal
THE IMPACT OF PNEUMOCOCCAL CONJUGATE VACCINE INTRODUCTION IN NEPAL: A SIX-YEAR PAEDIATRIC SURVEILLANCE STUDY (ID 516)
- Shrijana Shrestha, Nepal
- Meeru Gurung, Nepal
- Stephen Thorson, Nepal
- Bhishma Pokhrel, Nepal
- Bibek Khadka, Nepal
- Pratistha Maskey, Nepal
- Puja Amatya, Nepal
- Madhav C. Gautam, Nepal
- Michael J. Carter, United Kingdom
- Rama Kandasamy, Australia
- Brian Wahl, United States of America
- Sarah Kelly, United Kingdom
- Krishna G. Prajapati, Nepal
- Sonu Shrestha, United Kingdom
- Maria Deloria Knoll, United States of America
- Jason Hinds, United Kingdom
- Ganesh Shah, Nepal
- Dominic Kelly, United Kingdom
- David Murdoch, New Zealand
- Merryn Voysey, United Kingdom
- Andrew J. Pollard, United Kingdom
Abstract
Background
S. pneumoniae is a major cause of bacterial pneumonia and an important cause of invasive bacterial disease (IBD) in children under-five years of age in Nepal. Pneumococcal conjugate vaccine, PCV10, was introduced in 2015 with a 2+1 schedule.
Methods
We assessed the programmatic impact of PCV10 introduction using surveillance for nasopharyngeal (NP) colonisation, pneumonia and IBD. NP swabs from pneumonia inpatients and from healthy children, blood cultures from inpatients with suspected IBD, and chest x-rays from inpatient pneumonia cases were obtained over a 6-year period (2014-2019).
Results
The proportion of pneumonia cases with radiographic endpoint-consolidation (likely bacterial) was 34% lower (95%CI 19-46%) in 2018 compared with the pre-vaccine period (2014-2015). Vaccine serotype (VT) carriage in children under 2-years of age with pneumonia in 2019 was 78% lower (95%CI 30-93%) than in the pre-vaccine period.
Among healthy 6-23 month old children (urban and rural cohorts), VT-carriage declined 74% (95%CI 43-82%) by 2019. An increase in PCV13-additional-serotype carriage was seen in 2018 among rural-children (prevalence-ratio 1.65, 95%CI 1.17-2.32), but not urban-children.
Serotype 1 remains the dominant serotype detected in cases of invasive pneumococcal disease.
Conclusions
A decrease in prevalence of endpoint-consolidation-pneumonia and a decrease in vaccine-serotype circulation have been observed post PCV introduction in Nepal.
IS THERE A RELATIONSHIP BETWEEN PREVIOUS HISTORY OF PNEUMONIA, MENINGITIS OR SEPSIS AND NASOPHARYNGRAL CARRIAGE OF STREPTOCOCCUS PNEUMONIAE IN HEALTHY CHILDREN IN NEPAL (ID 752)
- Himang M. Maskey, Nepal
- Meeru Gurung, Nepal
- Sanjeev M. Bijukchhe, Nepal
- Peter J. O'Reilly, United Kingdom
- Pratistha Maskey, Nepal
- Subhash Shrestha, Nepal
- Stephen Thorson, Nepal
- Bhishma Pokhrel, Nepal
- Ganesh Shah, Nepal
- Imran Ansari, Nepal
- Sarah Kelly, United Kingdom
- Merryn Voysey, United Kingdom
- Maria Deloria Knoll, United States of America
- Dominic Kelly, United Kingdom
- David Murdoch, New Zealand
- Andrew J. Pollard, United Kingdom
- Shrijana Shrestha, Nepal
NASOPHARYNGEAL CARRIAGE PREVALENCE OF SEROTYPES 3, 6A, 19A AND 6C IN NEPALESE CHILDREN: IS IT TIME TO SWITCH FROM PCV10 TO A DIFFERENT PCV? (ID 528)
- Pratistha Maskey, Nepal
- Meeru Gurung, Nepal
- Sanjeev M. Bijukchhe, Nepal
- Peter J. O'Reilly, United Kingdom
- Himang M. Maskey, Nepal
- Subhash Shrestha, Nepal
- Stephen Thorson, Nepal
- Madhav C. Gautam, Nepal
- Bhishma Pokhrel, Nepal
- Ganesh Shah, Nepal
- Imran Ansari, Nepal
- Sarah Kelly, United Kingdom
- Merryn Voysey, United Kingdom
- Maria Deloria Knoll, United States of America
- Dominic Kelly, United Kingdom
- David Murdoch, New Zealand
- Andrew J. Pollard, United Kingdom
- Shrijana Shrestha, Nepal