Nazma Begum, Bangladesh

Projahnmo Research Foundation Filed studies

Author Of 1 Presentation

EFFECT OF NATIONAL INTRODUCTION OF 10-VALENT PNEUMOCOCCAL CONJUGATE VACCINE ON INVASIVE PNEUMOCOCCAL DISEASES IN BANGLADESH: A POPULATION-BASED STUDY (ID 471)

Abstract

Background

Bangladesh introduced 10-valent pneumococcal conjugate vaccine (PCV10) in its national immunization program in early 2015. We conducted case-control, incident trend and indirect cohort analyses to assess PCV impact on invasive pneumococcal diseases (IPD).

Methods

To assess PCV impact on IPD, we established community and facility-based surveillance in Bangladesh’s Sylhet district. Children 3-35 months of age attending study clinics were assessed for suspected IPD. Blood and CSF were collected from suspected IPD cases to isolate pneumococcus using culture and molecular tests. Community and clinic controls were matched to each IPD case. Data on immunization status and potential confounders were collected from cases and controls.

Results

During July 2015-June 2018, 94,584 children 3-35-month-old were under surveillance. Of these, 32,021 sought care from study clinics. We enrolled 44 IPD cases, 158 clinic and 173 community controls. Case-control analysis using clinic controls showed 89.6% (95% CI: -26.0 to 99.1) and using community controls showed 83.1% (95% CI:1.57 to 97.1) effectiveness in preventing vaccine type IPD. Time trend analysis estimated 80.1% (95% CI: 38.4, 93.6) effectiveness, and the indirect cohort analysis estimated 76.1% (95% CI: 17.3, 93.1) effectiveness with 3 doses of PCV.

Conclusions

PCV in our population is highly effective in preventing IPD.

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