Background

Invasive pneumococcal disease (IPD) is associated with high mortality and healthcare utilization. This analysis assessed IPD and unspecified invasive disease incidence rates (IRs) following PCV13 introduction in 2010 in Veneto.

Methods

IPD and unspecified invasive disease episodes in children <15 years in the Veneto region were identified in the Pedianet database from 2010-2017. IPD and unspecified invasive disease included pneumococcal and unspecified bacteremia, meningitis and septicemia. IRs were numbers of episodes/100,000 person-years. Interrupted time series (ITS) analyses assessed trends in annual IRs in the early and late PCV13 (2010-2013, 2014-2017) periods.

Results

We identified 81 episodes of IPD and unspecified invasive disease over the analysis period of which 94% were associated with non-specific codes.

IPD and unspecified invasive disease incidence decreased from 40/100,000 person-years (95% CI: 17-63/100,000 person-years) in 2010 to 31/100,000 person-years (95% CI: 6-56/100,000 person-years) in 2017 in children <15 years. While incidence was numerically lower in 2017 than in 2010, ITS analysis did not detect a significant trend in the early (coef=1.97; p=0.63) or late PCV13 (coef=0.50; p=0.90) periods.

Conclusions

Results did not show a significant decrease in IPD and unspecified invasive disease incidence in children <15 years after PCV13 introduction in Veneto.