A RETROSPECTIVE DATABASE ANALYSIS TO ESTIMATE THE BURDEN OF PNEUMONIA IN CHILDREN
Streptococcus pneumoniae is a leading cause of bacterial pneumonia in children. This analysis assessed pneumonia incidence rates (IRs) and expenditures following PCV13 introduction in 2010 in Veneto.
Outpatient pneumococcal and unspecified pneumonia episodes in children <15 years in the Veneto Region were identified in the Pedianet database from 2010-2017. IRs were numbers of episodes/1,000 person-years. Interrupted time series (ITS) analysis were conducted to assess trends in annual IRs in the early and late PCV13 (2010-2013, 2014-2017) periods.
Incidence was higher in children 2-4 years, compared to children <2 and 5-14 years. IRs declined from 14/1,000 person-years in 2010 to 5/1,000 person-years in 2017 in the total cohort.
In ITS analysis, a significant downward trend was detected in the late PCV13 period (p =0.0027) with rates declining by 2.8% annually in children under 15 years. Mann-Kendall test showed a significant negative correlation over the analysis period (coef=-0.64, p=0.026). Similar results were found for children 2-4 and 5-14 years but not in children < 2 years.
Total regional expenditures declined from €472,573 in 2010 to €157,865 in 2017.
Results demonstrate a decrease in outpatient pneumonia incidence and regional expenditures in children <15 years after PCV13 introduction with greater benefits in older children.