FREQUENCY, CLINICAL AND MICROBIOLOGICAL CHARACTERISTICS, AND OUTCOMES OF PRIMARY BACTEREMIA BY STREPTOCOCCUS PNEUMONIAE IN CHILDREN TREATED AT COLOMBIAN TERTIARY CARE CENTERS 2017 - 2019
- Stephanie Sanchez, Colombia
- Juan P. Rojas, Colombia
- Robinson Pacheco, Colombia
- German Camacho Moreno, Colombia
- Aura L. Leal Castro, Colombia
- Jaime A. Patiño Niño, Colombia
- Vivian M. Moreno Mejia, Colombia
- Ivan F. Gutierrez Tobar, Colombia
- Sandra Beltran, Colombia
- Cristina Mariño, Colombia
- Martha I. Alvarez-Olmos, Colombia
- Rocio Barrero Barreto, Colombia
- Fabio Espinosa, Colombia
- Catalina Arango, Colombia
- Maria A. Suarez, Colombia
- Monica Trujillo, Colombia
- Eduardo López, Colombia
- Pio López, Colombia
- Wilfrido Coronell, Colombia
- Hernando Pinzon, Colombia
- Nicolas Ramos, Colombia
- Anita Montañez, Colombia
Invasive pneumococcal disease is a common cause of morbidity and mortality among children, with a case fatality rate of about 8% in children under 5 years. The frequency of primary bacteremia is 20% of the IPD in children under 2 years.
Observational, descriptive, longitudinal study. Data were obtained from 40 medical records of patients under 18 years diagnosed with bacteremia by pneumococcus and treated in Neumocolombia network hospitals in 2017-2019. A univariate analysis was performed using frequency and bivariate tables with non-parametric Kruskal-Wallis.
60% of the patients were male. Median age was 24 months (IQR 10 - 48). 52% of the patients were under the age of 2; lethality was 10% and immunization with PCV was 10 50%. The most frequent serotype was 19A, followed by 23B, and 25A(20%, 7.5% and 5.0%, respectively). Resistance to erythromycin was 37.5%, to clindamycin 32.5%, penicillin 22.5% and ceftriaxone 15%. 30% of the children were admitted to the ICU. The average hospital stay was 11 days, and 2.5 days in the ICU.
Primary bacteremia by S. pneumoniae in Colombia has a 10% case fatality rate in children under 2 years, the most frequent serotype being 19A. Penicillin resistance was found in 22.5%.