RESISTANCE OF STREPTOCOCCUS PNEUMONIAE ISOLATES CAUSING INVASIVE PNEUMOCOCCAL DISEASE IN 17 HOSPITALS OF COLOMBIA.
- Aura L. Leal Castro, Colombia
- German Camacho Moreno, Colombia
- Jaime A. Patiño Niño, Colombia
- Vivian M. Moreno Mejia, Colombia
- Ivan F. Gutierrez Tobar, Colombia
- Sandra Beltran, Colombia
- Martha I. Alvarez-Olmos, Colombia
- Cristina Mariño, Colombia
- Rocio Barrero Barreto, Colombia
- Juan P. Rojas, Colombia
- Fabio Espinosa, Colombia
- Catalina Arango, Colombia
- Maria A. Suarez, Colombia
- Monica Trujillo, Colombia
- Eduardo López, Colombia
- Pio López, Colombia
- Wilfrido Coronell, Colombia
- Hernando Pinzon, Colombia
- Nicolas Ramos, Colombia
- Anita Montañez, Colombia
Abstract
Background
Invasive Pneumococcal Disease (IPD) is a cause of morbidity and mortality in children. Some Streptococcus pneumoniae isolates are resistant to antibiotics used for IPD, such as beta-lactams and macrolides. Increased resistance has been reported in Colombia.
Methods
Ambispective case series study in pediatric patients with IPD admitted in 10 hospitals of Bogotá in 2008-2019, and 4 hospitals of Cali, 2 of Medellin and 1 of Cartagena in 2017-2019 (preliminary data).
Results
651 cases of IPD were found. Susceptibility profile information was obtained for 567(87%) isolates; 494(75.8%) were non-meningeal (NM) and 73(11.2%) meningeal (M). Regarding NM, 16.3% were penicillin-resistant, and 5.8% showed intermediate susceptibility; 5% were resistant to ceftriaxone and 9.5% had intermediate susceptibility. M showed 19.1% resistance to penicillin, 5.4% resistance to ceftriaxone, and 5.4% intermediate susceptibility. Resistance to macrolides was 26.2%, to clindamycin 19.7%, and trimethoprim sulfa 32%. All isolates were susceptible to vancomycin. Only 23.8% of the isolates were susceptible to all antibiotics; 36% were multi-resistant. The serotype most resistant to penicillin was 19A (26.8%), which was associated with multi-resistance.
Conclusions
An increase in antibiotic resistance is observed in relation to previous reports associated with emergence of multiresistant S. pneumoniae serotype 19A.
