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PNEUMOCOCCAL CARRIAGE IN PCV-10 VACCINATED HEALTHY AMERINDIAN KICHWA CHILDREN FROM ECUADOR: PREVALENCE, SEROTYPES AND ANTIBIOTIC SUSCEPTIBILITY. (ID 1236)

SEROTYPE-SPECIFIC ANTIBIOTIC NON-SUSCEPTIBILITY OF THE CLINICAL PNEUMOCOCCI IN SUZHOU, CHINA (ID 636)

STUDY ON EPIDEMIC CHARACTERISTICS AND ANTIBIOTICS SUSCEPTIBILITY OF STREPTOCOCCUS PNEUMONIAE IN CHILDREN WITH RESPIRATORY TRACT INFECTION IN SUZHOU (ID 640)

CHANGES IN PNEUMONIA HOSPITALISATIONS IN AUSTRALIAN INDIGENOUS CHILDREN FOLLOWING PNEUMOCOCCAL VACCINATION (ID 512)

Abstract

Background

Aboriginal and Torres Strait Islander (Indigenous) children in four Australian states/territories were funded from 2001 to receive 3 infant doses of 7-valent pneumococcal conjugate vaccine (7vPCV) followed by 23-valent pneumococcal polysaccharide vaccine in the second year of life. In 2011 all four doses were replaced with 13vPCV. We assessed impact of these vaccination programs on pneumonia hospitalisations in Indigenous children from 1999 to 2017.

Methods

We analysed hospitalisation data for Indigenous children aged <5 years with primary diagnosis of pneumonia and categorised into pneumococcal, unspecified, specified non-pneumococcal and all-cause using ICD-10-AM codes. Age-specific pneumonia hospitalisation rates (per 100,000) were calculated by year and rate changes by vaccine period.

Results

table 1.jpgOver the study duration from pre-7vPCV introduction (1999-2002) to post-13vPCV change (2014-2017) the hospitalisation rate declined by 53% (2811 to 1324/100,000) for all-cause, 85% (133 to 20/100,000) for pneumococcal and 66% (2449 to 842/100,000) for unspecified pneumonia, with the greatest declines in infants <12 months (Table 1). Between 2013-2017 all-cause pneumonia hospitalisations increased in children 12-23 months (1663 to 2859/100,000) and 2-4 years (569 to 828/100,000), largely driven by increasing specified non-pneumococcal pneumonia.

Conclusions

Large declines in pneumonia hospitalisations following 4-dose pneumococcal vaccination in Australian Indigenous children add to reductions in invasive disease previously documented.

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