ANTIBIOTIC SUSCEPTIBILITY OF STREPTOCOCCUS PNEUMONIAE IN SOUTHERN VIETNAM (ID 855)

Session Name
Clinical Sciences - Disease Burden in Infants, Children/Youth, and Adults
Presenter
  • Thi Trang Dai Vo, Viet Nam
Authors
  • Thi Trang Dai Vo, Viet Nam
  • Ha Thien My Ngo, Viet Nam
  • Thanh V. Phan, Viet Nam
  • Hoan Thi Pham, Viet Nam
  • Loc Thuy Ho Nguyen, Viet Nam

Abstract

Background

Streptococcus pneumoniae is a bacterial pathogen responsible for severe infections in children, especially meningitis. The emergence of multidrug-resistant S.pneumoniae, likely due to indiscriminate antibiotic use, is a serious public health problem in Vietnam. The aim of this study was to survey antimicrobial susceptibility of invasive S. pneumoniae isolates.

Methods

Twenty-five isolates from children <5 years old with meningitis in Southern Vietnam from 2012-2018 were serotyped by realtime PCR and Quellung reaction. Antimicrobial susceptibility was determined by Kirby Bauer (erythromycin, clindamycin, tetracycline, trimethoprim-sulfamethoxazole, chloramphenicol, levofloxacin, rifampin, vancomycin) and MIC methods (penicillin and ceftriaxone) with the data interpreted by CLSI, 2018.

Results

All pneumococcal isolates were non-susceptible to penicillin, erythromycin, clindamycin, and tetracycline, with 92%, 48%, and 20% non-susceptible to trimethoprim-sulfamethoxazole, ceftriaxone, and chloramphenicol, respectively. All isolates were susceptible to levofloxacin, rifampin, and vancomycin. All isolates were non-susceptible to multiple antibiotic classes (at least three classes of antibiotic) with serotype 6A and 6B isolates non-susceptible to most antibiotics tested. Furthermore, higher resistance rates were observed in this study compared to Southern Vietnam in previous periods.

Conclusions

Antibiotic resistance of invasive S. pneumoniae isolates from pediatric patients with meningitis in Southern Vietnam is alarmingly high. Strategies to combat pneumococcal antibiotic resistance are urgently needed.

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