E-POSTER GALLERY (ID 409)

P-0118 - Ambient Air Pollutants and Skin Cancer: Epidemiological Evidence from UK Biobank

Abstract Control Number
1625
Abstract Body
Background and aim: The impacts of air pollutants on skin cancer remain controversial due to different results of studies. The research aims to investigate the association between exposure to traffic-related pollutants and skin cancer in the United Kingdom (UK). Methods: The UK Biobank is a large population-based, prospective study with over half a million participants aged 40 to 60 years recruited from 2006 to 2010. Data on air pollutants including particulate matter (PM), nitrogen dioxide (NO2), and nitrogen oxides (NOx) between 2005 and 2010 were obtained. Binary logistic regression models were used to assess the association between the concentration of air pollutants and skin cancer after controlling for various confounders. Furthermore, a non-parametric classification tree model was used to evaluate the interactive effect of risk factors on the occurrence of skin cancer. Results: A total of 320,264 participants (48.7% men) aged 64±8 years were included in this study. During a median of 7.8 years of follow-up, 9164 cases of skin cancer occurred in UK. Our results showed that the concentration of air pollutants was a significantly negative correlation with skin cancer. For PM with an aerodynamic diameter of less than 2.5μm (PM2.5) and 10μm (PM10), the odds ratios (OR) were 0.953 (95% confidence interval [CI]: 0.927-0.979) and 0.937 (95%CI: 0.913-0.962) per interquartile range (IQR) increase, respectively. Similar results were observed on NO2 (OR: 0.923, 95%CI: 0.898-0.950) and NOx (OR: 0.940, 95%CI: 0.915-0.964) per IQR increase. The classification tree model showed interactive associations between risk factors and skin cancer. Conclusions: The research demonstrated that air pollutions may lower the risk of skin cancer in UK. However, further research is needed for examining the interactive relationship between air pollutants, ultraviolet index and skin cancer.