Xiangqun Ju (Australia)
The University of Adelaide Adelaide Dental SchoolPresenter of 1 Presentation
HUMAN PAPILLOMAVIRUS (HPV) TYPES ASSOCIATED WITH ORAL FOCAL EPITHELIAL HYPERPLASIA AMONG INDIGENOUS AUSTRALIANS (ID 133)
Abstract
Introduction
Focal Epithelial Hyperplasia (FEH) or Heck’s disease is caused by HPV types 13 or 32. The study aim was to estimate the prevalence of HPV13 and HPV32 among Indigenous Australians.
Methods
Data was obtained from a large convenience sample of Indigenous South Australians aged 18+ years. Data was collected from Feb 2018 to Jan 2019. Face to face interviews and saliva sample collections were undertaken by experienced Indigenous research officers. The interview included participants’ demographic characteristic (age, sex, residential location), social economic status (education level, household income), sexual health behaviours (have received/given oral sex), and health status (general/oral health and quality of life-‘EuroQol’). HPV DNA was tested using nested MY/GP+ PCR. All HPV DNA positive samples were sequenced to HPV type viral DNA sequences.
Results
A total 1,011 Australian Indigenous adults aged 18+ years took part. The overall prevalence of HPV13 and/or HPV32 infection was 20.6% (95% CI: 18.1%-23.1%). The prevalence of HPV13/32 infection was highest among those aged 30-39 years (28.2%, 95% CI: 22.1%-34.3%), residing in non-metropolitan locations (26.0%, 95% CI: 22.6%-29.4%), not owning their own car (25.4%, 95% CI: 21.3%-29.4%), chewing tobacco (44.4%, 95% CI: 25.7%-63.2%) and knowing little bit/not much about white fella ways (30.6%, 95% CI: 23.7%-37.5%). A higher prevalence of HPV 13/32 infection was additionally found among those reporting their general health as excellent/very good/good (22.3%, 95% CI: 19.1%-25.5%) and with no reported quality of life problems (as assessed by EuroQoL) (26.9%, 95% CI: 21.5%-32.3%).
Conclusions
The prevalence of HPV13 and HPV32 infections among Indigenous South Australians was associated with age, residential location, socio-economic factors, chewing tobacco status and self-rated health. There appeared to be no association with sexual behaviours.