The incidence of colorectal cancer cases is high and increases each year. Colorectal cancer is the 3rd most common cancer in both sexes. The five-year survival rate has not increased significantly for several decades. Usually our patients come to the hospital already in advanced stage and the elderly patients seem to have a better clinical outcome than young and adult patients. One factor that could be suggest for those cases is different immune profiles between them. We evaluated the difference of immune profiles between those groups in advanced stage colorectal cancer.
This was a cross sectional analytic study on colorectal cancer patients in advanced stage, to evaluate whether any difference in immunity profiles between 3 age groups (young: <40 y.o; adult: 40 – 60 y.o; elderly: >60 y.o). We evaluated the level of CRP, IL-1β, IL-6, IL-10 IFNγ, TNFα, CD-8, IG G and IG M from blood specimens of those colorectal cancer patients. MANOVA test was done to evaluate the level of significance of those differences between each age group.
62 colorectal cancer patients were evaluated on this study. We found significant differences in the levels of CRP, IL-6, IFNγ, CB-8, IG G and IG M between the young, adult and elderly patients, rp < 0.05. Whereas the difference between the young and adult patients, in the levels of IL-6, IFNγ, CD-8, IG G and IG M were found to be significant (p < 0.05), while between the young and elderly group, the signifant differences were in the levels of CRP, IL-6, IFNγ, CB-8, IG G and IG M (p < 0.05). The level of IL-6 was only significantly different between the adult and elderly group (p < 0.05)
There were significant differences in immune profile between young, adult and elderly colorectal cancer patients.
The authors.
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All authors have declared no conflicts of interest.