V. Dewan (Derby, GB)

Royal Derby Hospital

Presenter Of 1 Presentation

Poster Cartilage /Cell Transplantation

P084 - Long Term Outcomes And Survivorship Of Autologous Chondrocyte Implantation For Femoral Condyle Articular Cartilage Defects In The Knee

Presentation Topic
Cartilage /Cell Transplantation
Date
13.04.2022
Lecture Time
09:30 - 09:30
Room
Exhibition Foyer
Session Name
7.3 - Poster Viewing / Coffee Break / Exhibition
Session Type
Poster Session
Disclosure
No Significant Commercial Relationship

Abstract

Purpose

The aim of this study is to report long-term outcomes of ACI for isolated femoral condyle articular cartilage defects. The relationship between cell numbers, cell growth kinetics and clinical outcome will be discussed.

Methods and Materials

Prospectively collected data of 41 patients with a single medial or lateral femoral condyle articular cartilage lesion treated with ACI were identified from an in-house cell therapy database and analysed. The mean patient age was 36.5 years (±9.0, range 18-52) with 29 males and 12 females. Thirty lesions were on the medial femoral condyle and eleven were on the lateral femoral condyle. The mean area of defect was 4.38cm2 ±3.11 with the largest defect area measuring 13.5cm2. The mean number of cells implanted was 3.01 x 106 ±6.24 x 106 cells/cm2. Clinical outcome was determined annually using the modified Lysholm score, which was analysed using multilevel modelling. Kaplan-Meier survival analysis was performed using total knee replacement as the endpoint.

Results

The mean follow-up time was 11 years (± 5.03) with a maximum follow-up of 20 years post-ACI. The mean pre-operative Lysholm score was 43 ±17.16. Improvement in clinical outcome scores were found to peak between years 7-9 with a mean score of 61.0 (95% CI [54.3, 67.7]). Mean Lysholm scores at 10 and 20 years post-ACI were 60.9 (± 3.46) and 57.1 (± 6.98) respectively. Eight patients were considered to have failed with a conversion to total knee arthroplasty at a mean time of 8.1 years following ACI. Survival at 20 years was 74.4% (95% CI [60.3, 91.8]) with maintenance of the native knee for which treatment was initially sought.

Conclusion

The results show that ACI provides good survival rates and improved clinical outcome scores with enduring long-term results. It is a viable and valuable option for the management of isolated chondral defects in the femoral condyle of the knee

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Presenter Of 1 Presentation

Cartilage /Cell Transplantation

P084 - Long Term Outcomes And Survivorship Of Autologous Chondrocyte Implantation For Femoral Condyle Articular Cartilage Defects In The Knee

Abstract

Purpose

The aim of this study is to report long-term outcomes of ACI for isolated femoral condyle articular cartilage defects. The relationship between cell numbers, cell growth kinetics and clinical outcome will be discussed.

Methods and Materials

Prospectively collected data of 41 patients with a single medial or lateral femoral condyle articular cartilage lesion treated with ACI were identified from an in-house cell therapy database and analysed. The mean patient age was 36.5 years (±9.0, range 18-52) with 29 males and 12 females. Thirty lesions were on the medial femoral condyle and eleven were on the lateral femoral condyle. The mean area of defect was 4.38cm2 ±3.11 with the largest defect area measuring 13.5cm2. The mean number of cells implanted was 3.01 x 106 ±6.24 x 106 cells/cm2. Clinical outcome was determined annually using the modified Lysholm score, which was analysed using multilevel modelling. Kaplan-Meier survival analysis was performed using total knee replacement as the endpoint.

Results

The mean follow-up time was 11 years (± 5.03) with a maximum follow-up of 20 years post-ACI. The mean pre-operative Lysholm score was 43 ±17.16. Improvement in clinical outcome scores were found to peak between years 7-9 with a mean score of 61.0 (95% CI [54.3, 67.7]). Mean Lysholm scores at 10 and 20 years post-ACI were 60.9 (± 3.46) and 57.1 (± 6.98) respectively. Eight patients were considered to have failed with a conversion to total knee arthroplasty at a mean time of 8.1 years following ACI. Survival at 20 years was 74.4% (95% CI [60.3, 91.8]) with maintenance of the native knee for which treatment was initially sought.

Conclusion

The results show that ACI provides good survival rates and improved clinical outcome scores with enduring long-term results. It is a viable and valuable option for the management of isolated chondral defects in the femoral condyle of the knee

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