M. Wodzig (Margraten, NL)

Maastricht University Medical Centre Department of Orthopaedic Surgery

Presenter Of 1 Presentation

Podium Presentation Cartilage /Cell Transplantation

10.1.8 - Autologous Minced Cartilage as a One-Step Procedure for (Osteo)Chondral Lesions of the Knee: 12-Month Radiological & Clinical Results

Presentation Topic
Cartilage /Cell Transplantation
Date
13.04.2022
Lecture Time
13:54 - 14:03
Room
Potsdam 1
Session Type
Free Papers
Disclosure
No Significant Commercial Relationship

Abstract

Purpose

The aim of this study was to investigate early radiological and clinical outcome of autologous minced cartilage treatment as a single-step, low-cost treatment option in patients suffering from an osteochondral or chondral lesion of the knee.

Methods and Materials

This study was approved by the local ethical committee METC 2021-2898. 18 patients with an osteochondral or chondral lesion in the knee were included. Cartilage from healthy appearing loose bodies and/or the periphery of the defect were minced into small chips and sealed in the defect using fibrin glue (Figure 1). Magnetic resonance imaging (MRI) was performed preoperatively and at 3 and 12 months follow-up. The Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) 2.0 score was used to assess the cartilage repair tissue at 12 months. The International Knee Documentation Score (IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS), EuroQoL-5D (EQ-5D) , and Visual Analogue Scale pain (VAS) were collected preoperatively and 12 months after surgery.minced per operative.png

Results

MRI showed complete defect filling in 11 out of 14 patients who underwent MRI 3 months postoperatively. Mean MOCART 2.0 score at 12 months was 65±18.9 in 18 patients, with higher scores for lateral femoral chondral lesions compared to medial femoral chondral lesions (75.8±14.3, 52.5±15.8 respectively, P=0.02) (Figure 2). Clinical scores significantly improved from preoperative to 12 months postoperative: from 41.6±17.5 to 66.3±20.2 for IKDC (P= 0.005), from 46.7±16.5 to 72.4±15.6 for KOOS (P<0.001), and from 69.3±15.4 to 84.3±12.8 for EQ-5D (P=0.03). A significant decrease in VAS pain from 44 to 14 was measured (P=0.001).

mri minced cartilage.png

Conclusion

Treatment of chondral and osteochondral lesions using the autologous minced cartilage procedure resulted in good cartilage repair measured with MOCART 2.0. Significant improvements were observed in clinical scores. This study suggests autologous minced cartilage as a promising, single-step treatment for (osteo)chondral lesions.

Collapse

Presenter Of 1 Presentation

Cartilage /Cell Transplantation

P-10.1.8 - Autologous Minced Cartilage as a One-Step Procedure for (Osteo)Chondral Lesions of the Knee: 12-Month Radiological & Clinical Results