P. Conte (Rozzano, IT)
Istituto Clinico Humanitas Knee Functional and Biological Reconstruction CenterPresenter Of 1 Presentation
P242 - Evaluation of a Single Injection of Autologous Adipose Tissue Enriched in SVF in Severe Knee Osteoarthritis: Results at 18 Months of Follow-up
Abstract
Purpose
The pro-regenerative proprieties of mesenchymal stem cells (MSCs) were recently described. Most studies evaluating their use in knee osteoarthritis focus on early stages of knee degeneration and, to our knowledge, no studies evaluate the admnistration of adipose-derived MSCs exclusively in patients with severe KOA. Hence, a prospective clinical trial evaluating an intra-articular injection of autologous adipose tissue enriched in stromal vascular fraction (SVF) in patients with severe KOA was designed.
Methods and Materials
A prospective clinical trial has been designed to evaluate the clinical efficacy and safety of a single injection of autologous adipose tissue enriched in SVF in 42 patients with severe knee osteoarthritis (Kellgren-Lawrence IV). Patients will be followed for up to 5 years monitoring the variations of the following outcomes: KOOS, EQ-5D-5L, NRS, WORMS score for MRI, Joint Space Width on X-rays, the incidence rate and timing of any needed total knee replacement surgery and adverse effects.
Results
We present the preliminary results of the first 33 patients followed for 6 months, 17 of which reached the 12 months follow up and 5 the 18 months follow up. At a 6 months follow up mean improvements of 32.9 points for the KOOS for pain score (p <0.05), 20.3 for the KOOS for functionality score (p <0.05), and 4,19 points for the NRS score (p <0.05) were registered. At 12 months of follow up, the clinical results appeared stable if not improved. The initial evaluation of MRI variations showed a diffuse reduction of bone marrow edema and improvement of the WORMS score. Two patients had TKR and therefore left the study. No severe adverse reactions to the treatment occurred during the follow up.
Conclusion
Our preliminary results suggest that a single injection of autologous adipose tissue enriched in stromal vascular fraction is a safe and effective treatment in patients presenting severe knee osteoarthritis.
Presenter Of 1 Presentation
P242 - Evaluation of a Single Injection of Autologous Adipose Tissue Enriched in SVF in Severe Knee Osteoarthritis: Results at 18 Months of Follow-up
Abstract
Purpose
The pro-regenerative proprieties of mesenchymal stem cells (MSCs) were recently described. Most studies evaluating their use in knee osteoarthritis focus on early stages of knee degeneration and, to our knowledge, no studies evaluate the admnistration of adipose-derived MSCs exclusively in patients with severe KOA. Hence, a prospective clinical trial evaluating an intra-articular injection of autologous adipose tissue enriched in stromal vascular fraction (SVF) in patients with severe KOA was designed.
Methods and Materials
A prospective clinical trial has been designed to evaluate the clinical efficacy and safety of a single injection of autologous adipose tissue enriched in SVF in 42 patients with severe knee osteoarthritis (Kellgren-Lawrence IV). Patients will be followed for up to 5 years monitoring the variations of the following outcomes: KOOS, EQ-5D-5L, NRS, WORMS score for MRI, Joint Space Width on X-rays, the incidence rate and timing of any needed total knee replacement surgery and adverse effects.
Results
We present the preliminary results of the first 33 patients followed for 6 months, 17 of which reached the 12 months follow up and 5 the 18 months follow up. At a 6 months follow up mean improvements of 32.9 points for the KOOS for pain score (p <0.05), 20.3 for the KOOS for functionality score (p <0.05), and 4,19 points for the NRS score (p <0.05) were registered. At 12 months of follow up, the clinical results appeared stable if not improved. The initial evaluation of MRI variations showed a diffuse reduction of bone marrow edema and improvement of the WORMS score. Two patients had TKR and therefore left the study. No severe adverse reactions to the treatment occurred during the follow up.
Conclusion
Our preliminary results suggest that a single injection of autologous adipose tissue enriched in stromal vascular fraction is a safe and effective treatment in patients presenting severe knee osteoarthritis.