P122 - Clinical and T2-mapping Results of Meniscal Substitution with Cellularized Polyurethane Implants: 5-year Follow-up
- A. Olivos Meza (Mexico City, MX)
- A. Olivos Meza (Mexico City, MX)
- L. Murguía González (Mexico City, MX)
- J. Hernández León (Mexico City, MX)
- S. Cortés (Mexico City, MX)
- C. Landa Solis (Mexico City, MX)
- F. Pérez-Jiménez (Mexico City, MX)
- C. Ibarra (Mexico City, MX)
Abstract
Purpose
To evaluate the clinical results and chondroprotective effect of polyurethane meniscal substitution enhanced with mobilized mesenchymal stem cells versus acellular implants at 48-monthsTo evaluate the clinical results and chondroprotective effect of polyurethane meniscal substitution enhanced with mobilized mesenchymal stem cells versus acellular implants at 48-months
Methods and Materials
Seventeen patients between 18-50 years old with past meniscectomies were enrolled in 2 groups, first, acellular polyurethane scaffold or second one polyurethane scaffold enriched with mesenchymal stem cell. Patients in the cellular group received filgrastim to stimulate mesenchymal stem cells that were harvested and cultured in the polyurethane scaffold during 2 weeks. Then scaffolds were implanted arthroscopically into partial meniscus defects. Concomitant injuries were treated during the same procedure. Changes in the surface of articular cartilage adjacent to the meniscal substitution were evaluated by T2 mapping 60 months with clinical scores as well.
Results
In tibial and femur T2 mapping ROI values for the cellular group were decreased in compared with acellular group at 24 months (P > 0.05) this difference tended to be lower in both groups after 24 months with not significant difference. In the clinical scores, Tegner & KOOS-QOL increased significantly at 12m while Lysholm got better at 18 m (p > 0.05) in the cellular group (Tab.1). The rest of the scales didn`t show significant difference between groups (p > 0.05). Second look at 12-months showed complete integration without rupture or loss of the implant in any group (Fig. 1)
Conclusion
Polyurethane meniscal scaffolds enhanced with mobilized mesenchymal stem cells shows benefit only the first 24 months, after this time this group does not show any advantage either in the protection of articular cartilage or in clinical scores over acellular scaffolds.