Poster Biomaterials and Scaffolds

P059 - Treatment of Patellar Cartilage Lesion with a Chitosan-based Scaffold: Clinical and MRI Results at Minimum 2 years of Follow-up

Presentation Topic
Biomaterials and Scaffolds
Date
13.04.2022
Lecture Time
09:30 - 09:30
Room
Exhibition Foyer
Session Name
7.3 - Poster Viewing / Coffee Break / Exhibition
Session Type
Poster Session
Speaker
  • L. Andriolo (Bologna, IT)
Authors
  • L. Andriolo (Bologna, IT)
  • A. Di Martino (Bologna, IT)
  • A. Poggi (bologna, IT)
  • D. Reale (Bologna, IT)
  • A. Sessa (Bologna, IT)
  • A. Boffa (Bologna, IT)
  • G. Filardo (Bologna, IT)
  • S. Zaffagnini (Bologna, IT)
Disclosure
No Significant Commercial Relationship

Abstract

Purpose

New cartilage regeneration techniques based on scaffolds have been recently developed to improve the results of microfracture treatment, also in complex locations like the patello-femoral joint. The aim of this study was to analyze the clinical and MRI results obtained exclusively in patellar lesions treated with a bioscaffold, a solution composed by chitosan and glycerophosphate which forms a stable clot into the lesion.

Methods and Materials

In this study,15 patients with ICRS grade 3 and 4 cartilage lesions of the patellar surface were enrolled and treated with chitosan bioscaffold. The mean age of patients was 31.8 ± 11.9 and nine patients presented degenerative etiology, while four patients had previous trauma and one patient was affected by patellar osteochondritis dissecans. The mean area of patellar chondral lesion was 2.90 ± 0.97 cm2. Patients were clinically evaluated up to 24 months with IKDC, KOOS and Tegner scores and they underwent MRI evaluation at 24 months.

Results

A statistically significant improvement was reported for the clinical score analyzed. The IKDC subjective score improved from 46.2 ± 19.3 preoperatively to 69.5± 20.3 (p<0.05) and 74.1 ± 23.2 (p<0.05) at 12 and 24 months, respectively. A similar trend was found for KOOS Pain, KOOS Sport/Rec, KOOS QOL, showing a significant improvement from baseline to 12 months and to the final follow-up. Finally, the total MOCART 2.0 score at 24 months after surgery was 71.5 ± 13.6.

Conclusion

Chondral patellar lesions represent a complex pathology, with lower results compared to other sites, probably related to the biomechanical and biological complexity of the patellofemoral joint. The results of the present study showed that this scaffold represents a safe surgical treatment providing a significant clinical improvement in the treatment of patellar cartilage lesions at 24 months also confirmed by promising MRI results.

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